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Pnp2 purine-nucleoside phosphorylase 2 [ Mus musculus (house mouse) ]

Gene ID: 667034, updated on 2-Nov-2024

Summary

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Official Symbol
Pnp2provided by MGI
Official Full Name
purine-nucleoside phosphorylase 2provided by MGI
Primary source
MGI:MGI:3712328
See related
Ensembl:ENSMUSG00000068417 AllianceGenome:MGI:3712328
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including heterocyclic compound binding activity; phosphate ion binding activity; and purine-nucleoside phosphorylase activity. Predicted to be involved in several processes, including nucleoside catabolic process; positive regulation of interleukin-2 production; and purine-containing compound salvage. Predicted to be located in cytosol and extracellular region. Predicted to be active in cytoplasm. Is expressed in alimentary system and intestine. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 65.1), small intestine adult (RPKM 32.2) and 17 other tissues See more
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Genomic context

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See Pnp2 in Genome Data Viewer
Location:
14 C1; 14 26.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51193598..51202206)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50956141..50964751)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7308 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase Neighboring gene predicted gene, 38316 Neighboring gene STARR-seq mESC enhancer starr_36663 Neighboring gene predicted gene 8518 Neighboring gene ribonuclease, RNase A family, 10 (non-active)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior. Fan KQ, et al. Cell, 2019 Oct 31. PMID 31675497
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphate ion binding ISO
Inferred from Sequence Orthology
more info
  
enables purine nucleobase binding ISO
Inferred from Sequence Orthology
more info
  
enables purine-nucleoside phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-nucleoside phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in inosine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nicotinamide riboside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in purine-containing compound salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
purine-nucleoside phosphorylase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123371.2 → NP_001116843.1  purine-nucleoside phosphorylase 2

    See identical proteins and their annotated locations for NP_001116843.1

    Status: PROVISIONAL

    Source sequence(s)
    AK008143
    Consensus CDS
    CCDS49479.1
    UniProtKB/Swiss-Prot
    P23492, Q4FJT6
    UniProtKB/TrEMBL
    Q9D8C9
    Related
    ENSMUSP00000093615.5, ENSMUST00000095925.5
    Conserved Domains (2) summary
    COG0005
    Location:26 → 291
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    TIGR01700
    Location:41 → 295
    PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51193598..51202206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245151.4 → XP_011243453.2  purine-nucleoside phosphorylase 2 isoform X1

    UniProtKB/Swiss-Prot
    P23492, Q4FJT6
    Conserved Domains (1) summary
    cd09009
    Location:55 → 323
    PNP-EcPNPII_like; purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA)
Nucleotide Protein Strain
Heading Accession and Version

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