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Ifit1bl1 interferon induced protein with tetratricpeptide repeats 1B like 1 [ Mus musculus (house mouse) ]

Gene ID: 667373, updated on 2-Nov-2024

Summary

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Official Symbol
Ifit1bl1provided by MGI
Official Full Name
interferon induced protein with tetratricpeptide repeats 1B like 1provided by MGI
Primary source
MGI:MGI:3650685
See related
Ensembl:ENSMUSG00000079339 AllianceGenome:MGI:3650685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifit1c; Gm14446
Summary
Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 11.1), colon adult (RPKM 4.8) and 4 other tissues See more
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Genomic context

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See Ifit1bl1 in Genome Data Viewer
Location:
19 C1; 19 29.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34570288..34640382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34592888..34662981, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4275 Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c. Mears HV, et al. J Biol Chem, 2020 Dec 18. PMID 33454014, Free PMC Article
  2. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
  3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
  4. Postnatal gene expression in the normal mouse cornea by SAGE. Norman B, et al. Invest Ophthalmol Vis Sci, 2004 Feb. PMID 14744882
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
    Title: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to other organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon induced protein with tetratricpeptide repeats 1B like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101605.1 → NP_001095075.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' end exon compared to transcript variant 1, and encodes an isoform (2), which is the same length but differs by a single aa compared to isoform 1.
    Source sequence(s)
    AA175618, AC016791, BQ553020, BX515248, BY154335, DV551663
    Consensus CDS
    CCDS50422.1
    UniProtKB/TrEMBL
    E9PXF7
    Related
    ENSMUSP00000132781.2, ENSMUST00000168254.3
    Conserved Domains (5) summary
    sd00006
    Location:249 → 277
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:323 → 368
    TPR_11; TPR repeat
    pfam13424
    Location:62 → 132
    TPR_12; Tetratricopeptide repeat
    pfam13432
    Location:153 → 215
    TPR_16; Tetratricopeptide repeat
    cl21625
    Location:330 → 434
    Capsule_synth; Capsule polysaccharide biosynthesis protein

  2. NM_001110517.1 → NP_001103987.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform 1

    See identical proteins and their annotated locations for NP_001103987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AA175618, AA290456, AC016791, BB575849, BQ553020, BX515248, BY094379, DV551663
    Consensus CDS
    CCDS50421.1
    UniProtKB/TrEMBL
    D3Z6F0
    Related
    ENSMUSP00000108086.2, ENSMUST00000112467.2
    Conserved Domains (2) summary
    TIGR02917
    Location:63 → 468
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:249 → 277
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34570288..34640382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527265.5 → XP_006527328.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform X2

    Conserved Domains (2) summary
    TIGR02917
    Location:23 → 428
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:209 → 237
    TPR; TPR repeat [structural motif]

  2. XM_030251031.2 → XP_030106891.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform X1

    UniProtKB/TrEMBL
    D3Z6F0
    Conserved Domains (2) summary
    TIGR02917
    Location:63 → 468
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:249 → 277
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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