U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ube2w ubiquitin-conjugating enzyme E2W (putative) [ Mus musculus (house mouse) ]

Gene ID: 66799, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Ube2wprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2W (putative)provided by MGI
Primary source
MGI:MGI:1914049
See related
Ensembl:ENSMUSG00000025939 AllianceGenome:MGI:1914049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6130401J04Rik
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in cellular response to misfolded protein; protein monoubiquitination; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.9), cortex adult (RPKM 4.9) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ube2w in Genome Data Viewer
Location:
1 A3; 1 5.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (16611012..16689676, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (16540788..16619460, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene predicted gene 7568 Neighboring gene RIKEN cDNA C130013N14 gene Neighboring gene STARR-positive B cell enhancer ABC_E4305 Neighboring gene RIKEN cDNA D030040B21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5743 Neighboring gene elongin C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. UBE2W Improves the Experimental Colitis by Inhibiting the NF-κB Signaling Pathway. Wang S, et al. Dig Dis Sci, 2022 Dec. PMID 35314916
  2. UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis. Lei B, et al. Andrologia, 2020 Feb. PMID 31710394
  3. The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin. Wang B, et al. Neurobiol Dis, 2018 Jan. PMID 28986324, Free PMC Article
  4. Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems. Wang B, et al. J Biol Chem, 2016 Feb 5. PMID 26601958, Free PMC Article
  5. UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Zhang Y, et al. Mol Cells, 2011 Feb. PMID 21229326, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [UBE2W overexpression promotes proliferation of intestinal mucosal cells in mice with chemically induced colitis].
    Title: [UBE2W overexpression promotes proliferation of intestinal mucosal cells in mice with chemically induced colitis].
  2. UBE2W Improves the Experimental Colitis by Inhibiting the NF-kappaB Signaling Pathway.
    Title: UBE2W Improves the Experimental Colitis by Inhibiting the NF-κB Signaling Pathway.
  3. Expression levels of UBE2W in mouse testes were gradually elevated from 2 to 10 weeks, while were significantly deceased in the testes with hypospermatogenesis. When UBE2W expression was successfully down-regulated in spermatogenic cells, the rate of apoptosis was significantly increased and the P53/Bcl-2/caspase 6/caspase 9 signal pathways were activated.
    Title: UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
  4. Study shows the absence of ubiquitin conjugating enzyme Ube2W in HdhQ200 knock-in mice increases levels of soluble monomeric mutant huntingtin while reducing insoluble oligomeric species. This study sheds light on the potential function of the non-canonical ubiquitin-conjugating enzyme, Ube2W, in this polyQ neurodegenerative disease.
    Title: The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
  5. results establish that UBE2W is an important, albeit not essential, protein for early postnatal survival and normal functioning of multiple organ systems.
    Title: Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
  6. UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6.
    Title: UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin-conjugating enzyme E2 W
Names
E2 ubiquitin-conjugating enzyme W
N-terminal E2 ubiquitin-conjugating enzyme
N-terminus-conjugating E2
probable ubiquitin-conjugating enzyme E2 W
ubiquitin carrier protein W
ubiquitin-protein ligase W
NP_001257945.2
NP_001257946.2
NP_080049.3
XP_006495620.1
XP_011236704.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271016.3 → NP_001257945.2  ubiquitin-conjugating enzyme E2 W isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and has alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AC157362, AC162448
    Consensus CDS
    CCDS87815.1
    UniProtKB/TrEMBL
    Q3V321, S4R177
    Related
    ENSMUSP00000138110.3, ENSMUST00000182554.9
    Conserved Domains (1) summary
    cl00154
    Location:7 → 70
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001271017.2 → NP_001257946.2  ubiquitin-conjugating enzyme E2 W isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC162448, BY728312, CN663576
    Conserved Domains (1) summary
    cl00154
    Location:7 → 70
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_025773.4 → NP_080049.3  ubiquitin-conjugating enzyme E2 W isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC162448, AK082233, BY728312
    Consensus CDS
    CCDS48224.3
    UniProtKB/Swiss-Prot
    Q8BVJ8, Q8VDW4, Q9D5H3
    Related
    ENSMUSP00000112741.4, ENSMUST00000117146.9
    Conserved Domains (1) summary
    pfam00179
    Location:7 → 148
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. NR_073122.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC162448, BY728312, DV044691

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    16611012..16689676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238402.4 → XP_011236704.1  ubiquitin-conjugating enzyme E2 W isoform X2

    Conserved Domains (1) summary
    cl00154
    Location:36 → 99
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. XM_006495557.5 → XP_006495620.1  ubiquitin-conjugating enzyme E2 W isoform X1

    Conserved Domains (1) summary
    pfam00179
    Location:36 → 148
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. XR_003946406.2 RNA Sequence

  2. XR_004934078.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDW4.1 GenPept UniProtKB/Swiss-Prot:Q8VDW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous