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Tmt1a3 thiol methyltransferase 1A3 [ Mus musculus (house mouse) ]

Gene ID: 668178, updated on 2-Nov-2024

Summary

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Official Symbol
Tmt1a3provided by MGI
Official Full Name
thiol methyltransferase 1A3provided by MGI
Primary source
MGI:MGI:3710670
See related
Ensembl:ENSMUSG00000058057 AllianceGenome:MGI:3710670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubie3; Gm10035; Mettl7a3
Summary
Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 17.8), colon adult (RPKM 2.7) and 2 other tissues See more
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Genomic context

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See Tmt1a3 in Genome Data Viewer
Location:
15 F1; 15 56.27 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100232687..100246267)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100334806..100348386)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33666 Neighboring gene STARR-positive B cell enhancer ABC_E9423 Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A1 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene thiol methyltransferase 1A2 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA m(6)A methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiol S-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lncRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UbiE3 protein; ubiE3 protein
Names
methyltransferase like 7A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081471.1 → NP_001074940.1  UbiE3 protein

    See identical proteins and their annotated locations for NP_001074940.1

    Status: VALIDATED

    Source sequence(s)
    AB253945, AC124479
    Consensus CDS
    CCDS37209.1
    UniProtKB/TrEMBL
    G3X9G9, Q76I24
    Related
    ENSMUSP00000074875.5, ENSMUST00000075420.6
    Conserved Domains (1) summary
    pfam08241
    Location:75 → 172
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100232687..100246267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245712.3 → XP_011244014.1  ubiE3 protein isoform X2

    UniProtKB/TrEMBL
    H3BJI7
    Conserved Domains (1) summary
    pfam08241
    Location:75 → 166
    Methyltransf_11; Methyltransferase domain

  2. XM_006521279.5 → XP_006521342.1  ubiE3 protein isoform X1

    See identical proteins and their annotated locations for XP_006521342.1

    UniProtKB/TrEMBL
    Q76I24
    Conserved Domains (1) summary
    pfam08241
    Location:78 → 139
    Methyltransf_11; Methyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version

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