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Hmg20a high mobility group 20A [ Mus musculus (house mouse) ]

Gene ID: 66867, updated on 2-Nov-2024

Summary

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Official Symbol
Hmg20aprovided by MGI
Official Full Name
high mobility group 20Aprovided by MGI
Primary source
MGI:MGI:1914117
See related
Ensembl:ENSMUSG00000032329 AllianceGenome:MGI:1914117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibraf; Hmgxb1; 1200004E06Rik; 5730490E10Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including axial skeleton; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human HMG20A (high mobility group 20A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 21.5), whole brain E14.5 (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hmg20a in Genome Data Viewer
Location:
9 B; 9 30.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56325891..56404220)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56418619..56496936)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_24203 Neighboring gene STARR-seq mESC enhancer starr_24204 Neighboring gene STARR-positive B cell enhancer ABC_E1385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266337-56266490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266643-56266962 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56313127-56313350 Neighboring gene ubiquitin-conjugating enzyme E2S, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_24205 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56354440-56354627 Neighboring gene predicted gene, 53524 Neighboring gene STARR-seq mESC enhancer starr_24208 Neighboring gene STARR-seq mESC enhancer starr_24210 Neighboring gene predicted gene, 31529

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity. Lorenzo PI, et al. Theranostics, 2021. PMID 34093866, Free PMC Article
  2. Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Wynder C, et al. Nat Cell Biol, 2005 Nov. PMID 16227968
  3. The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Mellado-Gil JM, et al. Cell Death Dis, 2018 Feb 15. PMID 29449530, Free PMC Article
  4. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Sumoy L, et al. Cytogenet Cell Genet, 2000. PMID 10773667
  5. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Zhou J, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35074918, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.
    Title: The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.
  2. HMG20A is a key regulator of mature beta cell function in type 2 diabetes mellitus.
    Title: The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.
  3. ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
    Title: The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
  4. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
    Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
  5. Ectopic expression of iBRAF induces neuronal differentiation through recruitment of MLL, resulting in increased histone H3K4 trimethylation and activation of neuronal-specific genes.
    Title: Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
high mobility group protein 20A
Names
HMG box-containing protein 20A
HMG domain-containing protein HMGX1
inhibitor of BRAF35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025812.3 → NP_080088.1  high mobility group protein 20A

    See identical proteins and their annotated locations for NP_080088.1

    Status: VALIDATED

    Source sequence(s)
    AC159819
    Consensus CDS
    CCDS23208.1
    UniProtKB/Swiss-Prot
    Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2, Q9DC33
    Related
    ENSMUSP00000034879.4, ENSMUST00000034879.5
    Conserved Domains (2) summary
    cd01390
    Location:102 → 167
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    pfam17380
    Location:76 → 312
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56325891..56404220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155195.1 → XP_036011088.1  high mobility group protein 20A isoform X1

    UniProtKB/Swiss-Prot
    Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2, Q9DC33
    Conserved Domains (2) summary
    cd01390
    Location:102 → 167
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    pfam17380
    Location:76 → 312
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC33.1 GenPept UniProtKB/Swiss-Prot:Q9DC33

Gene LinkOut

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