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Serbp1 serpine1 mRNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66870, updated on 2-Nov-2024

Summary

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Official Symbol
Serbp1provided by MGI
Official Full Name
serpine1 mRNA binding protein 1provided by MGI
Primary source
MGI:MGI:1914120
See related
Ensembl:ENSMUSG00000036371 AllianceGenome:MGI:1914120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pairbp1; 1200009K13Rik; 9330147J08Rik
Summary
Enables ribosome binding activity; translation elongation factor binding activity; and translation repressor activity. Involved in ribosome hibernation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex; early conceptus; and ovary. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 69.9), liver E14 (RPKM 49.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Serbp1 in Genome Data Viewer
Location:
6 C1; 6 30.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67243963..67266286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67266979..67289302)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16173 Neighboring gene predicted gene, 38825 Neighboring gene STARR-seq mESC enhancer starr_16175 Neighboring gene Sod1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16176 Neighboring gene STARR-seq mESC enhancer starr_16180 Neighboring gene STARR-positive B cell enhancer ABC_E2787 Neighboring gene STARR-seq mESC enhancer starr_16184 Neighboring gene interleukin 12 receptor, beta 2 Neighboring gene predicted gene, 57761 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Smith PR, et al. Nat Commun, 2021 Nov 23. PMID 34815424, Free PMC Article
  2. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Kosti A, et al. Genome Biol, 2020 Aug 6. PMID 32762776, Free PMC Article
  3. miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas. Li L, et al. J Mol Endocrinol, 2021 Nov 26. PMID 34723832
  4. A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction. Heberlein KR, et al. Arterioscler Thromb Vasc Biol, 2012 May. PMID 22383705, Free PMC Article
  5. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. Zhang L, et al. Mol Cell Endocrinol, 2008 Jun 11. PMID 18440126

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas.
    Title: miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas.
  2. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
    Title: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
  3. Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
    Title: A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption.
  4. The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1).
    Title: Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation elongation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in PML body organization ISO
Inferred from Sequence Orthology
more info
  
involved_in PML body organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome hibernation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome hibernation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SERPINE1 mRNA-binding protein 1
Names
PAI-1 mRNA-binding protein
PAI-RBP1
PAI1 RNA-binding protein 1
plasminogen activator inhibitor 1 RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113564.1 → NP_001107036.1  SERPINE1 mRNA-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001107036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC130822, AK144764, BY083551
    Consensus CDS
    CCDS85061.1
    UniProtKB/TrEMBL
    Q3UMP4, Q3V274
    Related
    ENSMUSP00000144713.2, ENSMUST00000203436.3
    Conserved Domains (2) summary
    pfam04774
    Location:189 → 306
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5 → 119
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

  2. NM_001113565.1 → NP_001107037.1  SERPINE1 mRNA-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001107037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC130822, AK004678, AK010860
    Consensus CDS
    CCDS85060.1
    UniProtKB/TrEMBL
    Q3UJK2
    Related
    ENSMUSP00000144913.2, ENSMUST00000203077.3
    Conserved Domains (2) summary
    pfam04774
    Location:189 → 297
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5 → 119
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

  3. NM_001113566.1 → NP_001107038.1  SERPINE1 mRNA-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001107038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC130822, BC030502, BY083551
    Consensus CDS
    CCDS85062.1
    UniProtKB/TrEMBL
    Q3UEI6, Q3V274
    Related
    ENSMUSP00000145472.2, ENSMUST00000204293.3
    Conserved Domains (2) summary
    pfam04774
    Location:189 → 291
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5 → 152
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

  4. NM_025814.2 → NP_080090.2  SERPINE1 mRNA-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080090.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC130822, AK004678
    Consensus CDS
    CCDS20219.1
    UniProtKB/Swiss-Prot
    Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9CY58, Q9DBY6
    UniProtKB/TrEMBL
    Q3UJK2
    Related
    ENSMUSP00000039110.5, ENSMUST00000042990.7
    Conserved Domains (2) summary
    pfam04774
    Location:189 → 312
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5 → 119
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67243963..67266286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY58.2 GenPept UniProtKB/Swiss-Prot:Q9CY58

Gene LinkOut

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