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Cpne8 copine VIII [ Mus musculus (house mouse) ]

Gene ID: 66871, updated on 28-Oct-2024

Summary

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Official Symbol
Cpne8provided by MGI
Official Full Name
copine VIIIprovided by MGI
Primary source
MGI:MGI:1914121
See related
Ensembl:ENSMUSG00000052560 AllianceGenome:MGI:1914121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200003E11Rik; 1500031E20Rik
Summary
This gene encodes a member of the copine family of highly conserved, calcium-dependent phospholipid binding proteins. The encoded protein has two characteristic C2 domains and a VWFA domain and may play a role in membrane trafficking. A related pseudogene is found on chromosome 8. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 3.8), cortex adult (RPKM 2.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Cpne8 in Genome Data Viewer
Location:
15 E3; 15 45.21 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (90371684..90563591, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (90487481..90679388, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36480 Neighboring gene STARR-seq mESC enhancer starr_39480 Neighboring gene STARR-seq mESC enhancer starr_39481 Neighboring gene WEE1 homolog 2 pseudogene Neighboring gene mitochondrial ribosomal protein L30 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39482 Neighboring gene STARR-seq mESC enhancer starr_39484 Neighboring gene predicted gene 3861 Neighboring gene ribosomal protein L31, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, molecular characterization, and expression analysis of Copine 8. Maitra R, et al. Biochem Biophys Res Commun, 2003 Apr 11. PMID 12670487
  2. A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse. Lloyd SE, et al. Neurogenetics, 2010 May. PMID 19795140, Free PMC Article
  3. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. Creutz CE, et al. J Biol Chem, 1998 Jan 16. PMID 9430674
  4. The in vivo brain interactome of the amyloid precursor protein. Bai Y, et al. Mol Cell Proteomics, 2008 Jan. PMID 17934213
  5. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify Cpne8, a member of the copine family, as the most promising candidate gene for prion disease incubation time.
    Title: A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse.
  2. characterization of the human ortholog, CPNE8.
    Title: Cloning, molecular characterization, and expression analysis of Copine 8.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
copine-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033851.1 → NP_001029023.1  copine-8 isoform 2

    See identical proteins and their annotated locations for NP_001029023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region that leads to an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C terminus, compared to isoform 1.
    Source sequence(s)
    BC048551, BC076564
    Consensus CDS
    CCDS27759.1
    UniProtKB/TrEMBL
    Q9DB19
    Related
    ENSMUSP00000014777.9, ENSMUST00000014777.9
    Conserved Domains (1) summary
    cl14603
    Location:37 → 75
    C2; C2 domain

  2. NM_001357979.1 → NP_001344908.1  copine-8 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC099572, AC113493, AC116812
    UniProtKB/TrEMBL
    Q05D94
    Conserved Domains (2) summary
    cd04047
    Location:35 → 146
    C2B_Copine; C2 domain second repeat in Copine
    cd01459
    Location:156 → 412
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

  3. NM_025815.2 → NP_080091.1  copine-8 isoform 1

    See identical proteins and their annotated locations for NP_080091.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK004559, BB043122, BU846828
    Consensus CDS
    CCDS27758.1
    UniProtKB/Swiss-Prot
    B2RS65, Q9CUZ8, Q9DC53
    Related
    ENSMUSP00000067774.6, ENSMUST00000064391.12
    Conserved Domains (3) summary
    cd04047
    Location:171 → 282
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:37 → 158
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:292 → 548
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    90371684..90563591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248705.1 → XP_030104565.1  copine-8 isoform X1

    UniProtKB/TrEMBL
    Q05D94
    Conserved Domains (2) summary
    cd04047
    Location:1 → 108
    C2B_Copine; C2 domain second repeat in Copine
    cd01459
    Location:118 → 374
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC53.3 GenPept UniProtKB/Swiss-Prot:Q9DC53

Gene LinkOut

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