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Zdhhc6 zinc finger, DHHC domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 66980, updated on 2-Nov-2024

Summary

Official Symbol
Zdhhc6provided by MGI
Official Full Name
zinc finger, DHHC domain containing 6provided by MGI
Primary source
MGI:MGI:1914230
See related
Ensembl:ENSMUSG00000024982 AllianceGenome:MGI:1914230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-6; 2400007G07Rik; 5930409M18Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; heart; lung epithelium; and trunk somite. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 8.6), kidney adult (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Zdhhc6 in Genome Data Viewer
Location:
19 D2; 19 51.33 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55286648..55304468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55298216..55316036, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46491 Neighboring gene STARR-seq mESC enhancer starr_46492 Neighboring gene guanylate cyclase 2g Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:55328374-55328561 Neighboring gene STARR-positive B cell enhancer ABC_E8758 Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene predicted gene, 31595 Neighboring gene STARR-positive B cell enhancer ABC_E7673 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene STARR-seq mESC enhancer starr_46494 Neighboring gene STARR-seq mESC enhancer starr_46495 Neighboring gene STARR-seq mESC enhancer starr_46496 Neighboring gene STARR-seq mESC enhancer starr_46497 Neighboring gene STARR-seq mESC enhancer starr_46499 Neighboring gene STARR-positive B cell enhancer ABC_E2531 Neighboring gene STARR-positive B cell enhancer ABC_E2532 Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene STARR-positive B cell enhancer ABC_E7674 Neighboring gene STARR-positive B cell enhancer ABC_E11041 Neighboring gene predicted gene, 41871

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-stearoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-cysteine S-stearoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stearoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stearoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC6
Names
H4 homolog
stearoyltransferase ZDHHC6
zinc finger DHHC domain-containing protein 6
NP_001028745.1
NP_001347524.1
NP_080159.3
XP_006527331.1
XP_011245618.1
XP_030106892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033573.2NP_001028745.1  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_001028745.1

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK050388, AK159304, BY109555
    Consensus CDS
    CCDS29909.1
    UniProtKB/Swiss-Prot
    Q3U3I8, Q3UT70, Q544H1, Q9CPV7
    Related
    ENSMUSP00000076157.6, ENSMUST00000076891.7
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317396
    SH3_2; Variant SH3 domain
  2. NM_001360595.1NP_001347524.1  palmitoyltransferase ZDHHC6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133100
    Conserved Domains (1) summary
    pfam01529
    Location:95241
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_025883.4NP_080159.3  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_080159.3

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK159304
    Consensus CDS
    CCDS29909.1
    UniProtKB/Swiss-Prot
    Q3U3I8, Q3UT70, Q544H1, Q9CPV7
    Related
    ENSMUSP00000153014.2, ENSMUST00000224897.2
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317396
    SH3_2; Variant SH3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55286648..55304468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247316.3XP_011245618.1  palmitoyltransferase ZDHHC6 isoform X1

    See identical proteins and their annotated locations for XP_011245618.1

    UniProtKB/Swiss-Prot
    Q3U3I8, Q3UT70, Q544H1, Q9CPV7
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317396
    SH3_2; Variant SH3 domain
  2. XM_006527268.4XP_006527331.1  palmitoyltransferase ZDHHC6 isoform X1

    See identical proteins and their annotated locations for XP_006527331.1

    UniProtKB/Swiss-Prot
    Q3U3I8, Q3UT70, Q544H1, Q9CPV7
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317396
    SH3_2; Variant SH3 domain
  3. XM_030251032.1XP_030106892.1  palmitoyltransferase ZDHHC6 isoform X2

    Conserved Domains (1) summary
    pfam07653
    Location:213292
    SH3_2; Variant SH3 domain