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Actr6 ARP6 actin-related protein 6 [ Mus musculus (house mouse) ]

Gene ID: 67019, updated on 28-Oct-2024

Summary

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Official Symbol
Actr6provided by MGI
Official Full Name
ARP6 actin-related protein 6provided by MGI
Primary source
MGI:MGI:1914269
See related
Ensembl:ENSMUSG00000019948 AllianceGenome:MGI:1914269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp6; ArpX; CDA12; 2010200J04Rik
Summary
Predicted to enable nucleosome binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase I; nucleolus organization; and positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of Swr1 complex. Is expressed in ovary. Orthologous to human ACTR6 (actin related protein 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 6.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Actr6 in Genome Data Viewer
Location:
10 C2; 10 45.14 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89547828..89568184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89711966..89732319, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SCY1-like 2 (S. cerevisiae) Neighboring gene RIKEN cDNA 1500026H17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5164 Neighboring gene STARR-seq mESC enhancer starr_27523 Neighboring gene STARR-positive B cell enhancer ABC_E2334 Neighboring gene STARR-positive B cell enhancer ABC_E6899 Neighboring gene predicted gene, 30963 Neighboring gene bridge-like lipid transfer protein family member 3B Neighboring gene predicted gene, 31090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648
  2. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
  3. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Munger SC, et al. Genes Dev, 2009 Nov 1. PMID 19884258, Free PMC Article
  4. Network organization of the huntingtin proteomic interactome in mammalian brain. Shirasaki DI, et al. Neuron, 2012 Jul 12. PMID 22794259, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleolus organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleolus organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
actin-related protein 6
Names
ARP6 actin-related protein 6 homolog
mArp6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359468.2 → NP_001346397.1  actin-related protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130216
    Conserved Domains (1) summary
    smart00268
    Location:1 → 286
    ACTIN; Actin

  2. NM_001359469.1 → NP_001346398.1  actin-related protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130216, AK008409, CJ221252
    Conserved Domains (1) summary
    cl17037
    Location:1 → 199
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. NM_001429398.1 → NP_001416327.1  actin-related protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130216

  4. NM_001429399.1 → NP_001416328.1  actin-related protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130216

  5. NM_001429400.1 → NP_001416329.1  actin-related protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130216

  6. NM_001429401.1 → NP_001416330.1  actin-related protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130216

  7. NM_001429402.1 → NP_001416331.1  actin-related protein 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130216

  8. NM_001429403.1 → NP_001416332.1  actin-related protein 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130216

  9. NM_025914.3 → NP_080190.1  actin-related protein 6 isoform 1

    See identical proteins and their annotated locations for NP_080190.1

    Status: VALIDATED

    Source sequence(s)
    AK008409, CJ221252
    Consensus CDS
    CCDS24118.1
    UniProtKB/TrEMBL
    A0A0R4J009
    Related
    ENSMUSP00000020109.4, ENSMUST00000020109.5
    Conserved Domains (2) summary
    smart00268
    Location:2 → 394
    ACTIN; Actin
    COG5277
    Location:2 → 393
    COG5277; Actin-related protein [Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    89547828..89568184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513965.3 → XP_006514028.1  actin-related protein 6 isoform X1

    Conserved Domains (1) summary
    smart00268
    Location:10 → 312
    ACTIN; Actin

  2. XM_006513966.4 → XP_006514029.1  actin-related protein 6 isoform X1

    Conserved Domains (1) summary
    smart00268
    Location:10 → 312
    ACTIN; Actin

  3. XM_011243532.3 → XP_011241834.1  actin-related protein 6 isoform X2

    Conserved Domains (1) summary
    smart00268
    Location:1 → 286
    ACTIN; Actin

  4. XM_006513967.4 → XP_006514030.1  actin-related protein 6 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:1 → 199
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_030245223.1 → XP_030101083.1  actin-related protein 6 isoform X2

    Conserved Domains (1) summary
    smart00268
    Location:1 → 286
    ACTIN; Actin

  6. XM_036155958.1 → XP_036011851.1  actin-related protein 6 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:1 → 199
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  7. XM_030245224.1 → XP_030101084.1  actin-related protein 6 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:1 → 199
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D864.2 GenPept UniProtKB/Swiss-Prot:Q9D864

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