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Ccdc198 coiled-coil domain containing 198 [ Mus musculus (house mouse) ]

Gene ID: 67082, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc198provided by MGI
Official Full Name
coiled-coil domain containing 198provided by MGI
Primary source
MGI:MGI:1914332
See related
Ensembl:ENSMUSG00000021850 AllianceGenome:MGI:1914332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700011H14Rik
Summary
Involved in energy homeostasis. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including gut; metanephros; neural tube; testis; and yolk sac. Orthologous to human CCDC198 (coiled-coil domain containing 198). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 9.1), testis adult (RPKM 7.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc198 in Genome Data Viewer
Location:
14 C1; 14 25.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49463815..49482902, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49226358..49245445, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_36630 Neighboring gene solute carrier family 35, member F4 Neighboring gene STARR-seq mESC enhancer starr_36631 Neighboring gene predicted gene, 52146 Neighboring gene STARR-seq mESC enhancer starr_36633 Neighboring gene predicted gene, 22116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Petersen J, et al. Nat Commun, 2023 May 29. PMID 37248239, Free PMC Article
  2. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
  3. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
factor associated with metabolism and energy
Names
uncharacterized protein C14orf105 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025956.4 → NP_080232.3  factor associated with metabolism and energy

    See identical proteins and their annotated locations for NP_080232.3

    Status: VALIDATED

    Source sequence(s)
    AK005866, AK007176
    Consensus CDS
    CCDS26996.1
    UniProtKB/Swiss-Prot
    A9C481, Q8R0Q0, Q9CPZ1
    UniProtKB/TrEMBL
    A0A2K6EDK1
    Related
    ENSMUSP00000154726.2, ENSMUST00000228936.2
    Conserved Domains (1) summary
    pfam15398
    Location:1 → 292
    DUF4619; Domain of unknown function (DUF4619)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    49463815..49482902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519439.4 → XP_006519502.1  factor associated with metabolism and energy isoform X2

    UniProtKB/TrEMBL
    A0A2K6EDK1
    Related
    ENSMUSP00000022398.9, ENSMUST00000022398.15
    Conserved Domains (1) summary
    pfam15398
    Location:1 → 291
    DUF4619; Domain of unknown function (DUF4619)

  2. XM_011245156.4 → XP_011243458.1  factor associated with metabolism and energy isoform X1

    See identical proteins and their annotated locations for XP_011243458.1

    UniProtKB/Swiss-Prot
    A9C481, Q8R0Q0, Q9CPZ1
    UniProtKB/TrEMBL
    A0A2K6EDK1
    Conserved Domains (1) summary
    pfam15398
    Location:1 → 292
    DUF4619; Domain of unknown function (DUF4619)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPZ1.3 GenPept UniProtKB/Swiss-Prot:Q9CPZ1

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