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D16Ertd472e DNA segment, Chr 16, ERATO Doi 472, expressed [ Mus musculus (house mouse) ]

Gene ID: 67102, updated on 2-Nov-2024

Summary

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Official Symbol
D16Ertd472eprovided by MGI
Official Full Name
DNA segment, Chr 16, ERATO Doi 472, expressedprovided by MGI
Primary source
MGI:MGI:1196400
See related
Ensembl:ENSMUSG00000022864 AllianceGenome:MGI:1196400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eurl; 1700010I10Rik; 2310009O17Rik; E330003K22Rik
Summary
Involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human C21orf91 (chromosome 21 open reading frame 91). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 5.2), testis adult (RPKM 4.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See D16Ertd472e in Genome Data Viewer
Location:
16 C3.1; 16 45.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78337224..78373576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78540336..78576688, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 3 Neighboring gene predicted gene, 25038 Neighboring gene STARR-positive B cell enhancer ABC_E5553 Neighboring gene STARR-seq mESC enhancer starr_41307 Neighboring gene STARR-seq mESC enhancer starr_41309 Neighboring gene STARR-positive B cell enhancer ABC_E9935 Neighboring gene STARR-seq mESC enhancer starr_41310 Neighboring gene RIKEN cDNA 4930478L05 gene Neighboring gene STARR-positive B cell enhancer ABC_E4183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:78560476-78560629 Neighboring gene STARR-positive B cell enhancer mm9_chr16:78564961-78565261 Neighboring gene STARR-positive B cell enhancer ABC_E3169 Neighboring gene STARR-seq mESC enhancer starr_41311 Neighboring gene predicted gene, 24861 Neighboring gene RIKEN cDNA 4930570E03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Li SS, et al. Sci Rep, 2016 Jul 11. PMID 27404227, Free PMC Article
  2. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  3. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
  4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein EURL homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252438.1 → NP_001239367.1  protein EURL homolog

    See identical proteins and their annotated locations for NP_001239367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC098883, AK009258
    Consensus CDS
    CCDS28278.1
    UniProtKB/Swiss-Prot
    Q9D7G4
    UniProtKB/TrEMBL
    Q8VE27
    Related
    ENSMUSP00000156198.2, ENSMUST00000232052.2
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 284
    EURL; EURL protein

  2. NM_001252439.1 → NP_001239368.1  protein EURL homolog

    See identical proteins and their annotated locations for NP_001239368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC098883, AK005829, AW536354
    Consensus CDS
    CCDS28278.1
    UniProtKB/Swiss-Prot
    Q9D7G4
    UniProtKB/TrEMBL
    Q8VE27
    Related
    ENSMUSP00000109856.2, ENSMUST00000114218.2
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 284
    EURL; EURL protein

  3. NM_001252440.1 → NP_001239369.1  protein EURL homolog

    See identical proteins and their annotated locations for NP_001239369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC098883
    Consensus CDS
    CCDS28278.1
    UniProtKB/Swiss-Prot
    Q9D7G4
    UniProtKB/TrEMBL
    Q8VE27
    Related
    ENSMUSP00000109858.2, ENSMUST00000114220.9
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 284
    EURL; EURL protein

  4. NM_025967.4 → NP_080243.3  protein EURL homolog

    See identical proteins and their annotated locations for NP_080243.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC098883, AK044670, CN662712
    Consensus CDS
    CCDS28278.1
    UniProtKB/Swiss-Prot
    Q9D7G4
    UniProtKB/TrEMBL
    Q8VE27
    Related
    ENSMUSP00000109857.2, ENSMUST00000114219.8
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 284
    EURL; EURL protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    78337224..78373576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7G4.1 GenPept UniProtKB/Swiss-Prot:Q9D7G4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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