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Bfar bifunctional apoptosis regulator [ Mus musculus (house mouse) ]

Gene ID: 67118, updated on 2-Nov-2024

Summary

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Official Symbol
Bfarprovided by MGI
Official Full Name
bifunctional apoptosis regulatorprovided by MGI
Primary source
MGI:MGI:1914368
See related
Ensembl:ENSMUSG00000022684 AllianceGenome:MGI:1914368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bar; Rnf47; 3010001A07Rik; 3110001I22Rik
Summary
Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in central nervous system; heart valve; reproductive system; and urinary system. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 14.9), subcutaneous fat pad adult (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bfar in Genome Data Viewer
Location:
16 A1; 16 9.45 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13489722..13521476)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13671858..13703612)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40145 Neighboring gene predicted gene, 25276 Neighboring gene poly(A)-specific ribonuclease (deadenylation nuclease) Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene periphilin 1, pseudogene 1 Neighboring gene phospholipase A2, group X Neighboring gene phospholipase A2, group X, opposite strand Neighboring gene STARR-seq mESC enhancer starr_40155 Neighboring gene RIKEN cDNA A930007A09 gene Neighboring gene STARR-seq mESC enhancer starr_40157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3. Das A, et al. Proc Natl Acad Sci U S A, 2024 Feb 6. PMID 38294943, Free PMC Article
  2. BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy. Pei S, et al. J Exp Med, 2021 Jul 5. PMID 33914044, Free PMC Article
  3. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
  4. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
    Title: The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
  2. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism.
    Title: The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC48147

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables caspase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional apoptosis regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177552.1 → NP_001171023.1  bifunctional apoptosis regulator isoform 2

    See identical proteins and their annotated locations for NP_001171023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154607, AI255749, AK028592
    Consensus CDS
    CCDS49769.1
    UniProtKB/Swiss-Prot
    Q8R079
    Related
    ENSMUSP00000063371.8, ENSMUST00000069281.8
    Conserved Domains (2) summary
    cd00162
    Location:34 → 77
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl15755
    Location:98 → 124
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_025976.5 → NP_080252.1  bifunctional apoptosis regulator isoform 1

    See identical proteins and their annotated locations for NP_080252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154607, AI255749, AK013874
    Consensus CDS
    CCDS27966.1
    UniProtKB/Swiss-Prot
    Q8C1A7, Q8R079, Q9CXY3
    UniProtKB/TrEMBL
    A0A0R4J040
    Related
    ENSMUSP00000023365.7, ENSMUST00000023365.13
    Conserved Domains (3) summary
    cd09513
    Location:179 → 249
    SAM_BAR; SAM domain of BAR subfamily
    smart00454
    Location:179 → 248
    SAM; Sterile alpha motif
    cd00162
    Location:34 → 77
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13489722..13521476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025653.3: Suppressed sequence

    Description
    NM_025653.3: This RefSeq was removed because it is now thought that this transcript is produced by a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R079.1 GenPept UniProtKB/Swiss-Prot:Q8R079

Gene LinkOut

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