U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ikzf5 IKAROS family zinc finger 5 [ Mus musculus (house mouse) ]

Gene ID: 67143, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ikzf5provided by MGI
Official Full Name
IKAROS family zinc finger 5provided by MGI
Primary source
MGI:MGI:1914393
See related
Ensembl:ENSMUSG00000040167 AllianceGenome:MGI:1914393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEGASUS; Zfpn1a5; 2610034F18Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 6.4), liver E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ikzf5 in Genome Data Viewer
Location:
7 F3; 7 73.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130990378..131012243, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131388649..131410518, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene family with sequence similarity 24, member A Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene acyl-Coenzyme A dehydrogenase, short/branched chain Neighboring gene motile sperm domain containing 3 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Quick validation of genetic quality for conditional alleles in mice. Nakata H, et al. Genes Cells, 2021 Apr. PMID 33540482, Free PMC Article
  2. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Yeung F, et al. Nucleic Acids Res, 2012 Aug. PMID 22638570, Free PMC Article
  3. Ikaros confers early temporal competence to mouse retinal progenitor cells. Elliott J, et al. Neuron, 2008 Oct 9. PMID 18940586
  4. Ikaros promotes early-born neuronal fates in the cerebral cortex. Alsiö JM, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382203, Free PMC Article
  5. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Martín-Ibáñez R, et al. Development, 2017 Apr 15. PMID 28289129, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC106439

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein Pegasus
Names
ikaros family zinc finger protein 5
zinc finger protein, subfamily 1A, 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418761.1 → NP_001405690.1  zinc finger protein Pegasus isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156606

  2. NM_001418762.1 → NP_001405691.1  zinc finger protein Pegasus isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156606
    Related
    ENSMUSP00000113714.2, ENSMUST00000121033.8

  3. NM_001418763.1 → NP_001405692.1  zinc finger protein Pegasus isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156606
    UniProtKB/Swiss-Prot
    Q3U549, Q3USG0, Q8BU00, Q8BZR5

  4. NM_175115.5 → NP_780324.2  zinc finger protein Pegasus isoform 1

    See identical proteins and their annotated locations for NP_780324.2

    Status: VALIDATED

    Source sequence(s)
    AC156606
    Consensus CDS
    CCDS21915.1
    UniProtKB/Swiss-Prot
    Q3U549, Q3USG0, Q8BU00, Q8BZR5
    Related
    ENSMUSP00000035583.9, ENSMUST00000046306.15
    Conserved Domains (4) summary
    sd00017
    Location:84 → 104
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:366 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:124 → 148
    zf-H2C2_2; Zinc-finger double domain
    NF033913
    Location:216 → 352
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    130990378..131012243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153377.1 → XP_036009270.1  zinc finger protein Pegasus isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:45 → 65
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:57 → 81
    zf-H2C2_2; Zinc-finger double domain
    NF033913
    Location:149 → 285
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_036153376.1 → XP_036009269.1  zinc finger protein Pegasus isoform X1

    UniProtKB/Swiss-Prot
    Q3U549, Q3USG0, Q8BU00, Q8BZR5
    Conserved Domains (4) summary
    sd00017
    Location:84 → 104
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:366 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:124 → 148
    zf-H2C2_2; Zinc-finger double domain
    NF033913
    Location:216 → 352
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU00.1 GenPept UniProtKB/Swiss-Prot:Q8BU00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools