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Lrrc40 leucine rich repeat containing 40 [ Mus musculus (house mouse) ]

Gene ID: 67144, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc40provided by MGI
Official Full Name
leucine rich repeat containing 40provided by MGI
Primary source
MGI:MGI:1914394
See related
Ensembl:ENSMUSG00000063052 AllianceGenome:MGI:1914394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610040E16Rik
Summary
Predicted to be involved in intracellular signal transduction. Is expressed in genitourinary system. Orthologous to human LRRC40 (leucine rich repeat containing 40). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 11.4), placenta adult (RPKM 9.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc40 in Genome Data Viewer
Location:
3 H4; 3 81.65 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157742340..157772727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (158036682..158067090)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7952 Neighboring gene STARR-positive B cell enhancer ABC_E8807 Neighboring gene ankyrin repeat domain 13c Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208 Neighboring gene STARR-positive B cell enhancer ABC_E11232 Neighboring gene STARR-positive B cell enhancer ABC_E7953 Neighboring gene serine and arginine-rich splicing factor 11 Neighboring gene leucine rich repeat containing 7 Neighboring gene STARR-seq mESC enhancer starr_09391 Neighboring gene STARR-seq mESC enhancer starr_09392 Neighboring gene STARR-seq mESC enhancer starr_09393 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  2. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  3. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289524.2 → NP_001276453.1  leucine-rich repeat-containing protein 40 isoform b

    See identical proteins and their annotated locations for NP_001276453.1

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5
    Conserved Domains (4) summary
    cd00116
    Location:25 → 150
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:349 → 360
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:27 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:47 → 106
    LRR_8; Leucine rich repeat

  2. NM_001289525.2 → NP_001276454.1  leucine-rich repeat-containing protein 40 isoform b

    See identical proteins and their annotated locations for NP_001276454.1

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5
    Conserved Domains (4) summary
    cd00116
    Location:25 → 150
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:349 → 360
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:27 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:47 → 106
    LRR_8; Leucine rich repeat

  3. NM_001359763.2 → NP_001346692.1  leucine-rich repeat-containing protein 40 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC145301
    Conserved Domains (3) summary
    sd00031
    Location:444 → 455
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:7 → 29
    LRR_RI; leucine-rich repeat [structural motif]
    cl26793
    Location:20 → 454
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  4. NM_001426724.1 → NP_001413653.1  leucine-rich repeat-containing protein 40 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC145301

  5. NM_001426725.1 → NP_001413654.1  leucine-rich repeat-containing protein 40 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC145301

  6. NM_001426726.1 → NP_001413655.1  leucine-rich repeat-containing protein 40 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC145301

  7. NM_001426727.1 → NP_001413656.1  leucine-rich repeat-containing protein 40 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC145301

  8. NM_001426728.1 → NP_001413657.1  leucine-rich repeat-containing protein 40 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5

  9. NM_001426730.1 → NP_001413659.1  leucine-rich repeat-containing protein 40 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5

  10. NM_001426731.1 → NP_001413660.1  leucine-rich repeat-containing protein 40 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5

  11. NM_001426732.1 → NP_001413661.1  leucine-rich repeat-containing protein 40 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q78KN5

  12. NM_001426733.1 → NP_001413662.1  leucine-rich repeat-containing protein 40 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC145301

  13. NM_001426734.1 → NP_001413663.1  leucine-rich repeat-containing protein 40 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC145301

  14. NM_001426735.1 → NP_001413664.1  leucine-rich repeat-containing protein 40 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC145301

  15. NM_001426736.1 → NP_001413665.1  leucine-rich repeat-containing protein 40 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC145301

  16. NM_001426737.1 → NP_001413666.1  leucine-rich repeat-containing protein 40 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC145301

  17. NM_024194.7 → NP_077156.2  leucine-rich repeat-containing protein 40 isoform a

    See identical proteins and their annotated locations for NP_077156.2

    Status: VALIDATED

    Source sequence(s)
    AC145301
    Consensus CDS
    CCDS17935.1
    UniProtKB/Swiss-Prot
    Q78WQ9, Q8BS83, Q9CRC8
    UniProtKB/TrEMBL
    A0A0R4J0W6
    Related
    ENSMUSP00000071956.4, ENSMUST00000072080.10
    Conserved Domains (4) summary
    cd00116
    Location:101 → 368
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:567 → 578
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:84 → 106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:129 → 186
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157742340..157772727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRC8.2 GenPept UniProtKB/Swiss-Prot:Q9CRC8

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