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Parp10 poly (ADP-ribose) polymerase family, member 10 [ Mus musculus (house mouse) ]

Gene ID: 671535, updated on 2-Nov-2024

Summary

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Official Symbol
Parp10provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 10provided by MGI
Primary source
MGI:MGI:3712326
See related
Ensembl:ENSMUSG00000063268 AllianceGenome:MGI:3712326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD10; PARP-10
Summary
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; post-translational protein modification; and regulation of gene expression. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP10 (poly(ADP-ribose) polymerase family member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 25.0), adrenal adult (RPKM 24.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Parp10 in Genome Data Viewer
Location:
15 D3; 15 35.57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76117195..76127640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76232995..76243440, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39047 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene plectin Neighboring gene STARR-positive B cell enhancer ABC_E5489 Neighboring gene microRNA 1942 Neighboring gene microRNA 6953 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene myocardial infraction associated transcript 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8. Bütepage M, et al. Methods Mol Biol, 2018. PMID 30097860
  2. The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA. Gao XQ, et al. Nat Cell Biol, 2020 Nov. PMID 33020597
  3. Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes. Mihailovska E, et al. Mol Biol Cell, 2014 Dec 15. PMID 25318670, Free PMC Article
  4. Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity. Fuchs P, et al. J Biol Chem, 2009 Sep 25. PMID 19625254, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-lysine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein poly-ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP10
Names
ADP-ribosyltransferase diphtheria toxin-like 10
poly [ADP-ribose] polymerase 10
NP_001157047.1
NP_001157048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163575.1 → NP_001157047.1  protein mono-ADP-ribosyltransferase PARP10

    See identical proteins and their annotated locations for NP_001157047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK046755, BP768925, BY742887
    Consensus CDS
    CCDS49650.1
    UniProtKB/Swiss-Prot
    F6Z9X8, Q3TLV7, Q3U6C0, Q8BSZ1, Q8C8L6, Q8CIE4, Q8R133, Q8R1U9
    Related
    ENSMUSP00000075110.7, ENSMUST00000075689.7
    Conserved Domains (5) summary
    cd01439
    Location:834 → 952
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12547
    Location:9 → 79
    RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins
    pfam00644
    Location:768 → 954
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:755 → 876
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl17169
    Location:194 → 242
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001163576.1 → NP_001157048.1  protein mono-ADP-ribosyltransferase PARP10

    See identical proteins and their annotated locations for NP_001157048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK046755, BB843953, BP768925
    Consensus CDS
    CCDS49650.1
    UniProtKB/Swiss-Prot
    F6Z9X8, Q3TLV7, Q3U6C0, Q8BSZ1, Q8C8L6, Q8CIE4, Q8R133, Q8R1U9
    Related
    ENSMUSP00000129765.2, ENSMUST00000165738.8
    Conserved Domains (5) summary
    cd01439
    Location:834 → 952
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12547
    Location:9 → 79
    RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins
    pfam00644
    Location:768 → 954
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:755 → 876
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl17169
    Location:194 → 242
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76117195..76127640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIE4.1 GenPept UniProtKB/Swiss-Prot:Q8CIE4

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