SRI sorcin [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRIprovided by HGNC
Official Full Name: sorcinprovided by HGNC
Primary source: HGNC:HGNC:11292
See related: Ensembl:ENSG00000075142 MIM:182520; AllianceGenome:HGNC:11292
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCN; V19; CP22; CP-22
Summary: This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Expression: Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (88205115..88226976, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (89455604..89477464, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (87834430..87856291, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer.
Title: A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer.
Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
Title: Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.
Title: The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.
mir-1 inhibits migration of gastric cancer cells.
Title: mir-1 inhibits migration of gastric cancer cells.
Sorcin is an early marker of neurodegeneration, Ca(2+) dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.
Title: Sorcin is an early marker of neurodegeneration, Ca(2+) dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.
Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.
Title: Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.
REVIEW: the relationship of Sorcin with tumors as well as its regulatory mechanisms; Sorcin is increasingly considered as a potential molecular target for therapeutic intervention
Title: Soluble resistance-related calcium-binding protein in cancers.
Sorcin is able to limit the toxic effects of the chemotherapeutic agent in the cell. In addition, Sorcin silencing increases cell death upon treatment with doxorubicin, increases the accumulation of doxorubicin in cell nucleus, decreases the expression of MDR1 and doxorubicin efflux via MDR1.
Title: Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.
Sorcin overexpression in HCT116 cells resulted in a significant increase in cell migration and invasion. Sorcin stimulated epithelial-mesenchymal transition through activating PI3K/Akt signaling.
Title: Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer.
The authors verified that NS5A of hepatitis C virus interacted with sorcin through domain I of NS5A, and phosphorylation of the threonine residue 155 of sorcin played a crucial role in protein interaction.
Title: Nonstructural 5A Protein of Hepatitis C Virus Regulates Soluble Resistance-Related Calcium-Binding Protein Activity for Viral Propagation.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The interaction of HIV-1 CA with human cellular sorcin (SRI) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SRI (e-PCR)
- UniSTS:503580

D8S2279 (e-PCR)
- UniSTS:473907

D7S2744 (e-PCR)
- UniSTS:34166

D11S3114 (e-PCR)
- UniSTS:152207

D7S2348 (e-PCR)
- UniSTS:68513

RH68539 (e-PCR)
- UniSTS:48294

STS-N52223 (e-PCR)
- UniSTS:80585

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed
enables transmembrane transporter binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in intracellular sequestering of iron ion	TAS Traceable Author Statement more info	PubMed
involved_in muscle organ development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell communication by electrical coupling	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart contraction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of high voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of relaxation of muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
involved_in regulation of striated muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	TAS Traceable Author Statement more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromaffin granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in sarcoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sorcin

Names: 22 kDa protein; H_RG167B05.1; calcium binding protein amplified in mutlidrug-resistant cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032138.1 RefSeqGene

Range

5001..26877

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_414

mRNA and Protein(s)

NM_001256891.2 → NP_001243820.1 sorcin isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform C) with a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AC005075, AK296601, BI524104, DA268050

UniProtKB/Swiss-Prot

P30626

Conserved Domains (1) summary

cd00051
Location:75 → 130

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001256892.2 → NP_001243821.1 sorcin isoform D

See identical proteins and their annotated locations for NP_001243821.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a protein (isoform D) with shorter and distinct N- and C-termini, compared to isoform A.

Source sequence(s)

AC005075, AK296601

Consensus CDS

CCDS59063.1

UniProtKB/TrEMBL

C9J0K6

Related

ENSP00000391148.1, ENST00000431660.5

Conserved Domains (1) summary

cd16187
Location:19 → 175

EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
NM_003130.4 → NP_003121.1 sorcin isoform A

See identical proteins and their annotated locations for NP_003121.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).

Source sequence(s)

AC005075, AK129770, AK295225, AL117616, DA268050, DB540255

Consensus CDS

CCDS5612.1

UniProtKB/Swiss-Prot

A8MTH6, B4DKK2, D6W5Q0, P30626

Related

ENSP00000265729.3, ENST00000265729.7

Conserved Domains (1) summary

cd16187
Location:34 → 198

EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
NM_198901.2 → NP_944490.1 sorcin isoform B

See identical proteins and their annotated locations for NP_944490.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region and uses an alternate translational start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A.

Source sequence(s)

AC005075, AL117616, AL576812, BM739144, BM793972

Consensus CDS

CCDS47638.1

UniProtKB/TrEMBL

C9J0K6

Related

ENSP00000378137.3, ENST00000394641.7

Conserved Domains (1) summary

cd16187
Location:19 → 183

EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin