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Ube2t ubiquitin-conjugating enzyme E2T [ Mus musculus (house mouse) ]

Gene ID: 67196, updated on 18-Sep-2024

Summary

Official Symbol
Ube2tprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Tprovided by MGI
Primary source
MGI:MGI:1914446
See related
Ensembl:ENSMUSG00000026429 AllianceGenome:MGI:1914446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700084L22Rik
Summary
Predicted to enable chromatin binding activity; ubiquitin conjugating enzyme activity; and ubiquitin protein ligase binding activity. Predicted to be involved in DNA repair and protein ubiquitination. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; limb bud; nasal cavity epithelium; submandibular gland primordium; and thymus primordium. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group T. Orthologous to human UBE2T (ubiquitin conjugating enzyme E2 T). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 20.3), liver E14 (RPKM 12.2) and 14 other tissues See more
Orthologs
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Genomic context

See Ube2t in Genome Data Viewer
Location:
1 E4; 1 58.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134890303..134901918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134962565..134974180)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene predicted gene, 57568 Neighboring gene predicted gene, 51748 Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene microRNA 5104b Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene protein tyrosine phosphatase, non-receptor type 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (5) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K27-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K29-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 T
Names
E2 ubiquitin-conjugating enzyme T
ubiquitin carrier protein T
ubiquitin-conjugating enzyme E2T (putative)
ubiquitin-protein ligase T
NP_001265044.1
NP_080300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278115.1NP_001265044.1  ubiquitin-conjugating enzyme E2 T

    See identical proteins and their annotated locations for NP_001265044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK012565, BB872310, BY576015, CK334733
    Consensus CDS
    CCDS15313.1
    UniProtKB/Swiss-Prot
    Q9CQ37
    Conserved Domains (2) summary
    COG5078
    Location:1151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:5147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_026024.3NP_080300.1  ubiquitin-conjugating enzyme E2 T

    See identical proteins and their annotated locations for NP_080300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK012565, BB872310, BY576015
    Consensus CDS
    CCDS15313.1
    UniProtKB/Swiss-Prot
    Q9CQ37
    Related
    ENSMUSP00000027687.8, ENSMUST00000027687.8
    Conserved Domains (2) summary
    COG5078
    Location:1151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:5147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134890303..134901918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)