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Tmem19 transmembrane protein 19 [ Mus musculus (house mouse) ]

Gene ID: 67226, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem19provided by MGI
Official Full Name
transmembrane protein 19provided by MGI
Primary source
MGI:MGI:1914476
See related
Ensembl:ENSMUSG00000069520 AllianceGenome:MGI:1914476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810428F02Rik
Summary
Predicted to be active in membrane. Orthologous to human TMEM19 (transmembrane protein 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 21.5), liver adult (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem19 in Genome Data Viewer
Location:
10 D2; 10 63.51 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115176644..115198406, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115340739..115362522, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3916 Neighboring gene STARR-positive B cell enhancer ABC_E6923 Neighboring gene predicted gene 10752 Neighboring gene predicted gene, 53632 Neighboring gene STARR-seq mESC enhancer starr_27937 Neighboring gene STARR-seq mESC enhancer starr_27939 Neighboring gene STARR-seq mESC enhancer starr_27942 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene predicted gene, 53633 Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene zinc finger, C3H1-type containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359470.1 → NP_001346399.1  transmembrane protein 19 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153497, AK034298, AK138931, BB636118
    Consensus CDS
    CCDS88087.1
    Related
    ENSMUSP00000151334.2, ENSMUST00000217887.2
    Conserved Domains (1) summary
    pfam01940
    Location:74 → 337
    DUF92; Integral membrane protein DUF92

  2. NM_001359471.2 → NP_001346400.1  transmembrane protein 19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    Consensus CDS
    CCDS24178.1
    UniProtKB/Swiss-Prot
    Q3UU09, Q8BY23, Q8BZK7, Q91W52
    Conserved Domains (1) summary
    pfam01940
    Location:59 → 322
    DUF92; Integral membrane protein DUF92

  3. NM_001359472.2 → NP_001346401.1  transmembrane protein 19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    Consensus CDS
    CCDS24178.1
    UniProtKB/Swiss-Prot
    Q3UU09, Q8BY23, Q8BZK7, Q91W52
    Related
    ENSMUSP00000151753.2, ENSMUST00000217884.2
    Conserved Domains (1) summary
    pfam01940
    Location:59 → 322
    DUF92; Integral membrane protein DUF92

  4. NM_001429443.1 → NP_001416372.1  transmembrane protein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform 3.
    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7P6

  5. NM_001429444.1 → NP_001416373.1  transmembrane protein 19 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7P6

  6. NM_001429445.1 → NP_001416374.1  transmembrane protein 19 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7P6

  7. NM_001429446.1 → NP_001416375.1  transmembrane protein 19 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform 4.
    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7R5

  8. NM_001429447.1 → NP_001416376.1  transmembrane protein 19 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7R5

  9. NM_001429448.1 → NP_001416377.1  transmembrane protein 19 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126943, AC153497
    UniProtKB/TrEMBL
    A0A1W2P7R5

  10. NM_133683.5 → NP_598444.1  transmembrane protein 19 isoform 2

    See identical proteins and their annotated locations for NP_598444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform 2.
    Source sequence(s)
    AC126943, AC153497
    Consensus CDS
    CCDS24178.1
    UniProtKB/Swiss-Prot
    Q3UU09, Q8BY23, Q8BZK7, Q91W52
    Related
    ENSMUSP00000089808.6, ENSMUST00000092170.7
    Conserved Domains (1) summary
    pfam01940
    Location:59 → 322
    DUF92; Integral membrane protein DUF92

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115176644..115198406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513978.3 → XP_006514041.1  transmembrane protein 19 isoform X2

    Related
    ENSMUSP00000151762.2, ENSMUST00000218731.2
    Conserved Domains (1) summary
    pfam01940
    Location:1 → 222
    DUF92; Integral membrane protein DUF92

  2. XM_006513977.2 → XP_006514040.1  transmembrane protein 19 isoform X2

    Conserved Domains (1) summary
    pfam01940
    Location:1 → 222
    DUF92; Integral membrane protein DUF92

  3. XM_036155960.1 → XP_036011853.1  transmembrane protein 19 isoform X1

    Conserved Domains (1) summary
    pfam01940
    Location:23 → 263
    DUF92; Integral membrane protein DUF92
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W52.1 GenPept UniProtKB/Swiss-Prot:Q91W52

Gene LinkOut

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