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SRPRA SRP receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 6734, updated on 7-Apr-2024

Summary

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Official Symbol
SRPRAprovided by HGNC
Official Full Name
SRP receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:11307
See related
Ensembl:ENSG00000182934 MIM:182180; AllianceGenome:HGNC:11307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP; SRPR; Sralpha
Summary
The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in thyroid (RPKM 41.3), salivary gland (RPKM 33.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (126235930..126268895, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (126265417..126298379, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126132833..126138790, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA pseudouridine synthase D4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5703 Neighboring gene family with sequence similarity 118 member B Neighboring gene RNA, U4 small nuclear 86, pseudogene Neighboring gene MPRA-validated peak1502 silencer Neighboring gene MPRA-validated peak1503 silencer Neighboring gene RNA, 7SL, cytoplasmic 351, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5705 Neighboring gene FAD dependent oxidoreductase domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126147427-126147591 Neighboring gene ribosomal protein L35a pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Complete cDNA sequence coding for human docking protein. Hortsch M, et al. Nucleic Acids Res, 1988 Jan 11. PMID 3340536, Free PMC Article
  2. The human docking protein does not associate with the membrane of the rough endoplasmic reticulum via a signal or insertion sequence-mediated mechanism. Hortsch M, et al. Biochem Biophys Res Commun, 1988 Jan 15. PMID 2827661
  3. PCR-assisted localization of the human SRPR gene. Janin N, et al. Hum Genet, 1992 Mar. PMID 1312991
  4. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Linder MI, et al. Blood, 2023 Feb 9. PMID 36223592, Free PMC Article
  5. The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. Tajima S, et al. J Cell Biol, 1986 Oct. PMID 3021779, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
    Title: Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3650, MGC9571, MGC17355

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding HDA PubMed 
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of signal recognition particle receptor complex EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
signal recognition particle receptor subunit alpha
Names
DP-alpha
SR-alpha
SRP receptor alpha subunit
SRP-alpha
docking protein alpha
signal recognition particle receptor (docking protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177842.2 → NP_001171313.1  signal recognition particle receptor subunit alpha isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AK303379, BC009110
    Consensus CDS
    CCDS53722.1
    UniProtKB/TrEMBL
    Q6IAX9
    Related
    ENSP00000435508.1, ENST00000532259.1
    Conserved Domains (2) summary
    pfam04086
    Location:27 → 234
    SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
    cl27330
    Location:269 → 608
    FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]

  2. NM_003139.4 → NP_003130.2  signal recognition particle receptor subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_003130.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK303379, BC009110
    Consensus CDS
    CCDS31717.1
    UniProtKB/Swiss-Prot
    A6NIB3, B2R5Z8, B4E0H3, E9PJS4, P08240, Q9BVJ4
    UniProtKB/TrEMBL
    Q6IAX9
    Related
    ENSP00000328023.5, ENST00000332118.11
    Conserved Domains (3) summary
    cd17876
    Location:419 → 635
    SRalpha_C; C-terminal domain of signal recognition particle receptor alpha subunit
    pfam02881
    Location:318 → 389
    SRP54_N; SRP54-type protein, helical bundle domain
    pfam04086
    Location:27 → 298
    SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    126235930..126268895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427497.1 → XP_047283453.1  signal recognition particle receptor subunit alpha isoform X1

  2. XM_017018179.3 → XP_016873668.1  signal recognition particle receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    Q6IAX9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    126265417..126298379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369754.1 → XP_054225729.1  signal recognition particle receptor subunit alpha isoform X1

  2. XM_054369755.1 → XP_054225730.1  signal recognition particle receptor subunit alpha isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08240.2 GenPept UniProtKB/Swiss-Prot:P08240

Gene LinkOut

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