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Unc50 unc-50 homolog [ Mus musculus (house mouse) ]

Gene ID: 67387, updated on 2-Nov-2024

Summary

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Official Symbol
Unc50provided by MGI
Official Full Name
unc-50 homologprovided by MGI
Primary source
MGI:MGI:1914637
See related
Ensembl:ENSMUSG00000026111 AllianceGenome:MGI:1914637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
URP; GMH1; UNCL; 1110002A21Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Located in Golgi apparatus. Orthologous to human UNC50 (unc-50 inner nuclear membrane RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.7), placenta adult (RPKM 30.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Unc50 in Genome Data Viewer
Location:
1 B; 1 15.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37469220..37478068)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37430139..37438987)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37374616-37374799 Neighboring gene inositol polyphosphate-4-phosphatase, type I Neighboring gene STARR-seq mESC enhancer starr_00675 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme A Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37528102-37528303 Neighboring gene STARR-positive B cell enhancer ABC_E1540 Neighboring gene G1 to S phase transition pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1541 Neighboring gene STARR-seq mESC enhancer starr_00677 Neighboring gene predicted gene, 39627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. de Chaldée M, et al. Genomics, 2006 Feb. PMID 16359841
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein unc-50 homolog
Names
PDLs22
periodontal ligament-specific protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356528.1 → NP_001343457.1  protein unc-50 homolog

    Status: VALIDATED

    Source sequence(s)
    AC084390
    Consensus CDS
    CCDS14892.1
    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Related
    ENSMUSP00000110575.4, ENSMUST00000114925.10
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  2. NM_026123.4 → NP_080399.1  protein unc-50 homolog

    See identical proteins and their annotated locations for NP_080399.1

    Status: VALIDATED

    Source sequence(s)
    AC084390, AK135885, AW124245
    Consensus CDS
    CCDS14892.1
    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Related
    ENSMUSP00000027285.7, ENSMUST00000027285.13
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37469220..37478068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496220.5 → XP_006496283.1  protein unc-50 homolog isoform X1

    See identical proteins and their annotated locations for XP_006496283.1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  2. XM_036153127.1 → XP_036009020.1  protein unc-50 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Related
    ENSMUSP00000123684.2, ENSMUST00000144617.8
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  3. XM_030242345.2 → XP_030098205.1  protein unc-50 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  4. XM_006496221.5 → XP_006496284.1  protein unc-50 homolog isoform X1

    See identical proteins and their annotated locations for XP_006496284.1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Related
    ENSMUSP00000113135.2, ENSMUST00000118059.3
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  5. XM_006496223.5 → XP_006496286.1  protein unc-50 homolog isoform X1

    See identical proteins and their annotated locations for XP_006496286.1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family

  6. XM_036153129.1 → XP_036009022.1  protein unc-50 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9CQ61
    UniProtKB/TrEMBL
    D3YXX4
    Conserved Domains (1) summary
    pfam05216
    Location:34 → 255
    UNC-50; UNC-50 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ61.1 GenPept UniProtKB/Swiss-Prot:Q9CQ61

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