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Srpra signal recognition particle receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 67398, updated on 2-Nov-2024

Summary

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Official Symbol
Srpraprovided by MGI
Official Full Name
signal recognition particle receptor alphaprovided by MGI
Primary source
MGI:MGI:1914648
See related
Ensembl:ENSMUSG00000032042 AllianceGenome:MGI:1914648
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srpr; D11Mgi27; 1300011P19Rik
Summary
Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Part of signal recognition particle receptor complex. Is expressed in cap mesenchyme; female associated reproductive structure; male associated reproductive structure; renal interstitium; and testis. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 54.6), placenta adult (RPKM 40.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Srpra in Genome Data Viewer
Location:
9 A4; 9 20.06 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35122499..35128299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35211203..35217003)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. Farber CR, et al. Physiol Genomics, 2009 May 13. PMID 19336533, Free PMC Article
  2. The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. Schlenker O, et al. J Biol Chem, 2006 Mar 31. PMID 16439358
  3. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal recognition particle binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of signal recognition particle receptor complex EXP
Inferred from Experiment
more info
 PubMed 
part_of signal recognition particle receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle receptor subunit alpha
Names
DP-alpha
SR-alpha
docking protein alpha
signal recognition particle receptor ('docking protein')

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026130.1 → NP_080406.1  signal recognition particle receptor subunit alpha

    See identical proteins and their annotated locations for NP_080406.1

    Status: PROVISIONAL

    Source sequence(s)
    AK004967
    Consensus CDS
    CCDS22959.1
    UniProtKB/Swiss-Prot
    Q8VC45, Q921H1, Q9DBG7
    Related
    ENSMUSP00000034541.6, ENSMUST00000034541.12
    Conserved Domains (4) summary
    smart00963
    Location:322 → 395
    SRP54_N; SRP54-type protein, helical bundle domain
    cd03115
    Location:417 → 613
    SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...
    TIGR00064
    Location:334 → 633
    ftsY; signal recognition particle-docking protein FtsY
    pfam04086
    Location:27 → 296
    SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35122499..35128299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBG7.1 GenPept UniProtKB/Swiss-Prot:Q9DBG7

Gene LinkOut

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