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Eps8l1 EPS8-like 1 [ Mus musculus (house mouse) ]

Gene ID: 67425, updated on 2-Nov-2024

Summary

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Official Symbol
Eps8l1provided by MGI
Official Full Name
EPS8-like 1provided by MGI
Primary source
MGI:MGI:1914675
See related
Ensembl:ENSMUSG00000006154 AllianceGenome:MGI:1914675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRC3; EPS8R1; 2310051G19Rik; 4632407K17Rik
Summary
Predicted to enable T cell receptor binding activity and actin filament binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within Rac protein signal transduction. Predicted to be located in cytosol and ruffle. Predicted to be part of protein-containing complex. Predicted to be active in ruffle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in stomach adult (RPKM 7.6), lung adult (RPKM 7.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Eps8l1 in Genome Data Viewer
Location:
7 A1; 7 2.58 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4463636..4483486)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4460638..4480487)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 6 platelet Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin T1, skeletal, slow

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Disanza A, et al. Nat Cell Biol, 2004 Dec. PMID 15558031
  2. In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure. Tocchetti A, et al. Genomics, 2003 Feb. PMID 12620401
  3. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Offenhäuser N, et al. Mol Biol Cell, 2004 Jan. PMID 14565974, Free PMC Article
  4. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731
  5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rac protein signal transduction ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISA
Inferred from Sequence Alignment
more info
 PubMed 
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 1
Names
EPS8-like protein 1
EPS8-related protein 1
epidermal growth factor receptor pathway substrate 8-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290416.1 → NP_001277345.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001277345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    AC161218, AK014556, AK019490
    Consensus CDS
    CCDS20736.1
    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Related
    ENSMUSP00000125840.2, ENSMUST00000163893.8
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. NM_001374622.1 → NP_001361551.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (2).
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS90151.1
    UniProtKB/TrEMBL
    E9Q4X5
    Related
    ENSMUSP00000133206.2, ENSMUST00000171445.8
    Conserved Domains (4) summary
    cd09540
    Location:683 → 748
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:542 → 594
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:220 → 307
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:93 → 223
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. NM_026146.4 → NP_080422.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    AC161218, AK009930, AK019490
    Consensus CDS
    CCDS20736.1
    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Related
    ENSMUSP00000083559.2, ENSMUST00000086372.8
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4463636..4483486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540324.3 → XP_006540387.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006540387.1

    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_017312258.1 → XP_017167747.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_006540325.4 → XP_006540388.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006540388.1

    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_006540326.2 → XP_006540389.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006540389.1

    UniProtKB/Swiss-Prot
    Q8R0D6, Q8R5F8, Q9D2M6
    Conserved Domains (4) summary
    cd09540
    Location:622 → 687
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 246
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RNA

  1. XR_391096.4 RNA Sequence

  2. XR_003946549.2 RNA Sequence

  3. XR_391095.5 RNA Sequence

  4. XR_003946548.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5F8.1 GenPept UniProtKB/Swiss-Prot:Q8R5F8

Gene LinkOut

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