U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abhd5 abhydrolase domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 67469, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Abhd5provided by MGI
Official Full Name
abhydrolase domain containing 5provided by MGI
Primary source
MGI:MGI:1914719
See related
Ensembl:ENSMUSG00000032540 AllianceGenome:MGI:1914719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IECN5; NCIE2; CGI-58; 1300003D03Rik; 2010002J10Rik
Summary
Enables lipase activator activity. Involved in negative regulation of sequestering of triglyceride and positive regulation of triglyceride catabolic process. Located in cytosol and lipid droplet. Is expressed in central nervous system; dorsal root ganglion; heart; retina; and skin. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 60.2), liver E18 (RPKM 34.9) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Abhd5 in Genome Data Viewer
Location:
9 F4; 9 73.03 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122180681..122210589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122351616..122381524)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35289 Neighboring gene STARR-seq mESC enhancer starr_25547 Neighboring gene predicted gene, 35398 Neighboring gene STARR-seq mESC enhancer starr_25548 Neighboring gene RIKEN cDNA A730085K08 gene Neighboring gene STARR-seq mESC enhancer starr_25549 Neighboring gene STARR-seq mESC enhancer starr_25550 Neighboring gene predicted gene, 35454

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice. Xie P, et al. Endocrinology, 2015 May. PMID 25751639, Free PMC Article
  2. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise. Brícola RS, et al. Cell Biochem Funct, 2023 Jan. PMID 36515301
  3. Identification of a novel splicing isoform of murine CGI-58. Yang X, et al. FEBS Lett, 2010 Mar 5. PMID 20083112, Free PMC Article
  4. Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling. Yang D, et al. Cell Physiol Biochem, 2016. PMID 26872126
  5. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. Brown JM, et al. J Lipid Res, 2010 Nov. PMID 20802159, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
    Title: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
  2. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.
    Title: Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.
  3. suppresses spermidine synthase-dependent spermidine production in tumour-associated macrophages and potentiates the growth of colorectal cancer
    Title: Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.
  4. Mice lacking brown adipose tissue CGI-58 gene, a lipolytic activator essential for the stimulated lipid droplet lipolysis, have normal thermogenic capacity and are not cold sensitive.
    Title: Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
  5. Prebinding CGI-58 with PI(3)P or PI(5)P did not alter its coactivation of ATGL in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL coactivator lacks LPAAT activity.
    Title: Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity.
  6. CGI-58 regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.
    Title: Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.
  7. ABHD5 possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.
    Title: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.
  8. omega-O-AcylCer and CLE formation critically depend on CGI-58 expression in differentiated keratinocytes.
    Title: Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.
  9. These results demonstrate that macrophage CGI-58 enhances PPAR-gamma signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction in macrophages.
    Title: Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling.
  10. Here, we identify synthetic ligands that release ABHD5 from PLIN1 or PLIN5 without PKA activation and rapidly activate adipocyte and muscle lipolysis.
    Title: Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidic acid acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Names
abhydrolase domain-containing protein 5
lipid droplet-binding protein CGI-58
NP_001346136.1
NP_080455.1
XP_030100386.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359207.1 → NP_001346136.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108846
    Consensus CDS
    CCDS90688.1
    Related
    ENSMUSP00000107123.4, ENSMUST00000111497.5
    Conserved Domains (1) summary
    PLN02894
    Location:19 → 194
    PLN02894; hydrolase, alpha/beta fold family protein

  2. NM_026179.2 → NP_080455.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1

    See identical proteins and their annotated locations for NP_080455.1

    Status: VALIDATED

    Source sequence(s)
    AK004873, AK050377, CN840045
    Consensus CDS
    CCDS23646.1
    UniProtKB/Swiss-Prot
    Q9CTY3, Q9DBL9
    Related
    ENSMUSP00000122274.2, ENSMUST00000156520.8
    Conserved Domains (1) summary
    PLN02894
    Location:3 → 347
    PLN02894; hydrolase, alpha/beta fold family protein

RNA

  1. NR_152865.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108846

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122180681..122210589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244526.2 → XP_030100386.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1

    Conserved Domains (1) summary
    PLN02894
    Location:53 → 304
    PLN02894; hydrolase, alpha/beta fold family protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBL9.1 GenPept UniProtKB/Swiss-Prot:Q9DBL9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools