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Narf nuclear prelamin A recognition factor [ Mus musculus (house mouse) ]

Gene ID: 67608, updated on 2-Nov-2024

Summary

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Official Symbol
Narfprovided by MGI
Official Full Name
nuclear prelamin A recognition factorprovided by MGI
Primary source
MGI:MGI:1914858
See related
Ensembl:ENSMUSG00000000056 AllianceGenome:MGI:1914858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4430402O11Rik
Summary
Predicted to enable lamin binding activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in lamin filament. Is expressed in liver lobe; nervous system; and neural retina. Orthologous to human NARF (nuclear prelamin A recognition factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 24.8), liver E14.5 (RPKM 24.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Narf in Genome Data Viewer
Location:
11 E2; 11 85.12 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121128062..121146682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121237236..121255856)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7117 Neighboring gene hexosaminidase D Neighboring gene STARR-positive B cell enhancer ABC_E5315 Neighboring gene STARR-seq mESC enhancer starr_31378 Neighboring gene STARR-positive B cell enhancer ABC_E8883 Neighboring gene cytochrome b 245 chaperone 1 Neighboring gene forkhead box K2 Neighboring gene WD repeat domain 45B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Yang Y, et al. Sci Adv, 2022 Dec 9. PMID 36490339, Free PMC Article
  2. Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy. Le Dour C, et al. J Lipid Res, 2017 Jan. PMID 27845687, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.
    Title: NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lamin binding IEA
Inferred from Electronic Annotation
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in lamin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamin filament IEA
Inferred from Electronic Annotation
more info
  
located_in lamin filament ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear lumen ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear prelamin A recognition factor
Names
IOP2
iron-only hydrogenase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026272.3 → NP_080548.3  nuclear prelamin A recognition factor

    See identical proteins and their annotated locations for NP_080548.3

    Status: VALIDATED

    Source sequence(s)
    AK081305, BC016090, BM951066
    Consensus CDS
    CCDS25772.1
    UniProtKB/Swiss-Prot
    Q8BVW9, Q9CYQ7
    Related
    ENSMUSP00000099304.4, ENSMUST00000103015.4
    Conserved Domains (3) summary
    smart00902
    Location:404 → 452
    Fe_hyd_SSU; Iron hydrogenase small subunit
    COG4624
    Location:49 → 449
    Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
    pfam02906
    Location:98 → 390
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121128062..121146682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYQ7.1 GenPept UniProtKB/Swiss-Prot:Q9CYQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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