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Yju2b YJU2 splicing factor homolog B [ Mus musculus (house mouse) ]

Gene ID: 67736, updated on 2-Nov-2024

Summary

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Official Symbol
Yju2bprovided by MGI
Official Full Name
YJU2 splicing factor homolog Bprovided by MGI
Primary source
MGI:MGI:1914986
See related
Ensembl:ENSMUSG00000004994 AllianceGenome:MGI:1914986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc130; 4930527D15Rik
Summary
Predicted to be involved in RNA splicing. Predicted to be located in nucleus. Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. Orthologous to human YJU2B (YJU2 splicing factor homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 9.6), CNS E14 (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Yju2b in Genome Data Viewer
Location:
8 C2; 8 40.77 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84984396..84997087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84257767..84270458, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E59 Neighboring gene zinc finger SWIM-type containing 4 Neighboring gene DNA segment, Chr 8, ERATO Doi 738, expressed Neighboring gene STARR-positive B cell enhancer ABC_E297 Neighboring gene STARR-positive B cell enhancer ABC_E10514 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86815694-86815995 Neighboring gene methylthioribose-1-phosphate isomerase 1 Neighboring gene THO complex 6 homolog pseudogene Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Neighboring gene predicted gene, 23626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable splicing factor YJU2B
Names
coiled-coil domain containing 130
coiled-coil domain-containing protein 130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294281.1 → NP_001281210.1  probable splicing factor YJU2B isoform 2

    See identical proteins and their annotated locations for NP_001281210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122794, AK015911, CJ148143
    Consensus CDS
    CCDS80906.1
    UniProtKB/Swiss-Prot
    Q9D516
    Related
    ENSMUSP00000005120.6, ENSMUST00000005120.12
    Conserved Domains (2) summary
    COG5134
    Location:8 → 191
    COG5134; Uncharacterized conserved protein [Function unknown]
    pfam04502
    Location:8 → 198
    DUF572; Family of unknown function (DUF572)

  2. NM_026350.3 → NP_080626.1  probable splicing factor YJU2B isoform 1

    See identical proteins and their annotated locations for NP_080626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122794, AK015911, CJ148143
    Consensus CDS
    CCDS40409.1
    UniProtKB/Swiss-Prot
    Q8VCB4, Q9D516
    UniProtKB/TrEMBL
    Q922B5
    Related
    ENSMUSP00000096177.4, ENSMUST00000098578.10
    Conserved Domains (1) summary
    pfam04502
    Location:9 → 384
    DUF572; Family of unknown function (DUF572)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84984396..84997087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531316.2 → XP_006531379.1  probable splicing factor YJU2B isoform X2

    UniProtKB/TrEMBL
    Q922B5
    Conserved Domains (1) summary
    pfam04502
    Location:1 → 268
    DUF572; Family of unknown function (DUF572)

  2. XM_006531315.5 → XP_006531378.1  probable splicing factor YJU2B isoform X1

    See identical proteins and their annotated locations for XP_006531378.1

    UniProtKB/Swiss-Prot
    Q8VCB4, Q9D516
    UniProtKB/TrEMBL
    Q922B5
    Conserved Domains (1) summary
    pfam04502
    Location:9 → 384
    DUF572; Family of unknown function (DUF572)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D516.1 GenPept UniProtKB/Swiss-Prot:Q9D516

Gene LinkOut

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