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Zmym4 zinc finger, MYM-type 4 [ Mus musculus (house mouse) ]

Gene ID: 67785, updated on 2-Nov-2024

Summary

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Official Symbol
Zmym4provided by MGI
Official Full Name
zinc finger, MYM-type 4provided by MGI
Primary source
MGI:MGI:1915035
See related
Ensembl:ENSMUSG00000042446 AllianceGenome:MGI:1915035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MYM; CDIR; Zfp262; Znf262; mKIAA0425; D630001M21; 6330503C17Rik
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in cytoskeleton organization and regulation of cell morphogenesis. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina nuclear layer; and thyroid gland. Orthologous to human ZMYM4 (zinc finger MYM-type containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 10.4), whole brain E14.5 (RPKM 8.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zmym4 in Genome Data Viewer
Location:
4 D2.2; 4 61.05 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126755612..126862021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126861819..126969377, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AU040320 Neighboring gene predicted gene, 24161 Neighboring gene STARR-positive B cell enhancer ABC_E4667 Neighboring gene predicted gene, 25604 Neighboring gene STARR-seq mESC enhancer starr_11411 Neighboring gene STARR-positive B cell enhancer ABC_E7989 Neighboring gene STARR-seq mESC enhancer starr_11413 Neighboring gene STARR-seq mESC enhancer starr_11417 Neighboring gene STARR-seq mESC enhancer starr_11418 Neighboring gene splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene zinc finger, MYM domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Marenne G, et al. Cell Metab, 2020 Jun 2. PMID 32492392, Free PMC Article
  2. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  3. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger MYM-type protein 4
Names
cell death inhibiting RNA
zinc finger protein 262

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114399.2 → NP_001107871.1  zinc finger MYM-type protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001107871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL606908, AL606985
    Consensus CDS
    CCDS51303.1
    UniProtKB/Swiss-Prot
    A2A791, Q3UFQ2, Q6ZQB9, Q80X47, Q8K1H5
    Related
    ENSMUSP00000101714.3, ENSMUST00000106108.9
    Conserved Domains (3) summary
    smart00746
    Location:389 → 429
    TRASH; metallochaperone-like domain
    pfam06467
    Location:478 → 521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1357 → 1526
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_001357201.2 → NP_001344130.1  zinc finger MYM-type protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606908, AL606985
    UniProtKB/TrEMBL
    F6VYE2
    Conserved Domains (2) summary
    pfam06467
    Location:481 → 521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1267 → 1436
    DUF3504; Domain of unknown function (DUF3504)

  3. NM_001379530.1 → NP_001366459.1  zinc finger MYM-type protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606908, AL606985
    Conserved Domains (3) summary
    smart00746
    Location:389 → 429
    TRASH; metallochaperone-like domain
    pfam06467
    Location:481 → 521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1356 → 1526
    DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126755612..126862021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503344.5 → XP_006503407.1  zinc finger MYM-type protein 4 isoform X1

    UniProtKB/TrEMBL
    F6VYE2
    Related
    ENSMUSP00000120813.2, ENSMUST00000135003.2
    Conserved Domains (2) summary
    pfam06467
    Location:481 → 521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1274 → 1438
    DUF3504; Domain of unknown function (DUF3504)

  2. XM_030253729.1 → XP_030109589.1  zinc finger MYM-type protein 4 isoform X2

    Conserved Domains (3) summary
    smart00746
    Location:500 → 538
    TRASH; metallochaperone-like domain
    pfam06467
    Location:450 → 490
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1332 → 1496
    DUF3504; Domain of unknown function (DUF3504)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A791.1 GenPept UniProtKB/Swiss-Prot:A2A791

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