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STIM1 stromal interaction molecule 1 [ Homo sapiens (human) ]

Gene ID: 6786, updated on 27-Nov-2024

Summary

Official Symbol
STIM1provided by HGNC
Official Full Name
stromal interaction molecule 1provided by HGNC
Primary source
HGNC:HGNC:11386
See related
Ensembl:ENSG00000167323 MIM:605921; AllianceGenome:HGNC:11386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E
Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in thyroid (RPKM 23.4), esophagus (RPKM 23.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See STIM1 in Genome Data Viewer
Location:
11p15.4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3854604..4093210)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3919928..4158475)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3875834..4114440)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902618 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3841189-3841380 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene uncharacterized LOC124902619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3876149-3877094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4315 Neighboring gene Sharpr-MPRA regulatory region 4669 Neighboring gene ras homolog family member G Neighboring gene STIM1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3093 Neighboring gene microRNA 4687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4317 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3915212-3915428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4318 Neighboring gene Sharpr-MPRA regulatory region 4967 Neighboring gene peptidylprolyl isomerase A pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4319 Neighboring gene Sharpr-MPRA regulatory region 12872 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 76 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 21 Neighboring gene ribosomal protein S29 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 1570 Neighboring gene Sharpr-MPRA regulatory region 9588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4321 Neighboring gene ribonucleotide reductase catalytic subunit M1 Neighboring gene olfactory receptor family 55 subfamily B member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with STIM1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Tat tat HIV-1 Tat modulates STIM1 expression in neuron cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25614, FLJ33037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel regulator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016277.1 RefSeqGene

    Range
    5001..242508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_164

mRNA and Protein(s)

  1. NM_001277961.3NP_001264890.1  stromal interaction molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001264890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as STIM1L, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC015689, AC087441, AC090804
    Consensus CDS
    CCDS73247.1
    UniProtKB/TrEMBL
    A0A8V8TMG5, G0XQ39
    Related
    ENSP00000478059.1, ENST00000616714.4
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
    cl25732
    Location:237434
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001277962.2NP_001264891.1  stromal interaction molecule 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001264891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as STIM1B (PMID:33730587) contains an alternate exon and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 3, STIM1B) has a distinct C-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC090804, AK314928, HQ317451, U52426
    Consensus CDS
    CCDS60706.1
    UniProtKB/Swiss-Prot
    Q13586
    UniProtKB/TrEMBL
    G0XQ39
    Related
    ENSP00000436208.1, ENST00000527651.5
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
  3. NM_001382566.1NP_001369495.1  stromal interaction molecule 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91420.1
    UniProtKB/TrEMBL
    A0A8V8TMG5, A0A8V8TNW0
    Related
    ENSP00000514025.1, ENST00000698911.1
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  4. NM_001382567.1NP_001369496.1  stromal interaction molecule 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as STIM1A (PMID:34942054), contains an alternate exon and uses an alternate in-frame splice site, relative to variant 1. The resulting protein (isoform 5, STIM1A) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015689, AC087441, AC090804
    Consensus CDS
    CCDS91417.1
    UniProtKB/TrEMBL
    H0YDB2, V5J3L2
    Related
    ENSP00000433266.2, ENST00000526596.2
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region
  5. NM_001382568.1NP_001369497.1  stromal interaction molecule 1 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    UniProtKB/TrEMBL
    V5J3L2
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237441
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344448
    SOAR; STIM1 Orai1-activating region
  6. NM_001382569.1NP_001369498.1  stromal interaction molecule 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    UniProtKB/TrEMBL
    V5J3L2
    Conserved Domains (3) summary
    cd09573
    Location:83156
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:192389
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:299396
    SOAR; STIM1 Orai1-activating region
  7. NM_001382570.1NP_001369499.1  stromal interaction molecule 1 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    UniProtKB/TrEMBL
    V5J3L2
    Conserved Domains (2) summary
    COG1196
    Location:161358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:268365
    SOAR; STIM1 Orai1-activating region
  8. NM_001382571.1NP_001369500.1  stromal interaction molecule 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    UniProtKB/TrEMBL
    E9PNJ4
    Conserved Domains (3) summary
    COG1196
    Location:77274
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:184281
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:641
    SAM_superfamily; SAM (Sterile alpha motif )
  9. NM_001382572.1NP_001369501.1  stromal interaction molecule 1 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    Consensus CDS
    CCDS91416.1
    UniProtKB/TrEMBL
    A0A8V8TMF0
    Related
    ENSP00000514028.1, ENST00000698914.1
    Conserved Domains (2) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237323
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  10. NM_001382573.1NP_001369502.1  stromal interaction molecule 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090587
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  11. NM_001382574.1NP_001369503.1  stromal interaction molecule 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090587
    Conserved Domains (2) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163249
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. NM_001382575.1NP_001369504.1  stromal interaction molecule 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 14 and 15, encodes isoform 13.
    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91419.1
    UniProtKB/TrEMBL
    A0A8V8TP73, V5J3L2
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  13. NM_001382576.1NP_001369505.1  stromal interaction molecule 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15, encodes isoform 13.
    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91419.1
    UniProtKB/TrEMBL
    A0A8V8TP73, V5J3L2
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  14. NM_001382577.1NP_001369506.1  stromal interaction molecule 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 13 and 14, encodes isoform 13.
    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91419.1
    UniProtKB/TrEMBL
    A0A8V8TP73, V5J3L2
    Related
    ENSP00000514027.1, ENST00000698913.1
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  15. NM_001382578.1NP_001369507.1  stromal interaction molecule 1 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 14.
    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91418.1
    UniProtKB/TrEMBL
    E9PRZ7
    Related
    ENSP00000432210.2, ENST00000525403.6
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  16. NM_001382579.1NP_001369508.1  stromal interaction molecule 1 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 14.
    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91418.1
    UniProtKB/TrEMBL
    E9PRZ7
    Related
    ENSP00000514026.1, ENST00000698912.1
    Conserved Domains (3) summary
    cd09573
    Location:54127
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:163360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:270367
    SOAR; STIM1 Orai1-activating region
  17. NM_001382580.1NP_001369509.1  stromal interaction molecule 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090587
    Conserved Domains (3) summary
    COG1196
    Location:74271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:181278
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:138
    SAM_superfamily; SAM (Sterile alpha motif )
  18. NM_001382581.1NP_001369510.1  stromal interaction molecule 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090587
    Consensus CDS
    CCDS91421.1
    UniProtKB/TrEMBL
    A0A8V8TMG1, E9PNJ4
    Related
    ENSP00000514024.1, ENST00000698910.1
    Conserved Domains (3) summary
    COG1196
    Location:74271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:181278
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:138
    SAM_superfamily; SAM (Sterile alpha motif )
  19. NM_003156.4NP_003147.2  stromal interaction molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_003147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as STIM1S, uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC015689, AC087441, AC090804
    Consensus CDS
    CCDS7749.1
    UniProtKB/Swiss-Prot
    E9PQJ4, Q13586, Q8N382
    UniProtKB/TrEMBL
    V5J3L2
    Related
    ENSP00000300737.4, ENST00000300737.8
    Conserved Domains (3) summary
    cd09573
    Location:128201
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    COG1196
    Location:237434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16533
    Location:344441
    SOAR; STIM1 Orai1-activating region

RNA

  1. NR_168436.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
  2. NR_168437.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    Related
    ENST00000698918.1
  3. NR_168438.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015689, AC087441, AC090804
    Related
    ENST00000698919.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3854604..4093210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3919928..4158475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)