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Enoph1 enolase-phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 67870, updated on 14-Nov-2024

Summary

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Official Symbol
Enoph1provided by MGI
Official Full Name
enolase-phosphatase 1provided by MGI
Primary source
MGI:MGI:1915120
See related
Ensembl:ENSMUSG00000029326 AllianceGenome:MGI:1915120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310057D15Rik
Summary
Predicted to enable acireductone synthase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Orthologous to human ENOPH1 (enolase-phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 19.1), adrenal adult (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Enoph1 in Genome Data Viewer
Location:
5 E4; 5 48.46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100186887..100216784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100039028..100068925)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene predicted gene, 42127 Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene transmembrane protein 150C Neighboring gene predicted gene, 36167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity. Barth A, et al. J Neurochem, 2014 Mar. PMID 24236849
  2. Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP. Yang D, et al. Exp Neurol, 2023 Jul. PMID 37075968
  3. Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Ditzen C, et al. Mol Psychiatry, 2010 Jul. PMID 19139748
  4. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Kim S, et al. Biol Psychiatry, 2009 Mar 1. PMID 18986647, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP.
    Title: Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP.
  2. Our result suggests a significant role for enoph1 and polyamines in anxiety and depression-related behaviors.
    Title: Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity.
  3. both single-nucleotide polymorphisms were significantly associated with locomotion-independent trait anxiety, further supporting a functional role of EP for this phenotype.
    Title: Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables acireductone synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acireductone synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables acireductone synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine ISO
Inferred from Sequence Orthology
more info
  
involved_in L-methionine salvage from methylthioadenosine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enolase-phosphatase E1
Names
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
MASA homolog
NP_001156507.1
NP_080697.2
XP_006535252.1
XP_006535253.1
XP_011247852.1
XP_030110635.1
XP_030110636.1
XP_036021337.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163035.1 → NP_001156507.1  enolase-phosphatase E1

    See identical proteins and their annotated locations for NP_001156507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK079062, AK080714, AK167575, BE995909
    Consensus CDS
    CCDS39183.1
    UniProtKB/Swiss-Prot
    Q3TGK8, Q3TXA2, Q3U8Y4, Q8BGB7, Q8VC92, Q9D6U4
    Related
    ENSMUSP00000031268.7, ENSMUST00000031268.8
    Conserved Domains (2) summary
    pfam13419
    Location:13 → 227
    HAD_2; Haloacid dehalogenase-like hydrolase
    cl21460
    Location:10 → 252
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_026421.3 → NP_080697.2  enolase-phosphatase E1

    See identical proteins and their annotated locations for NP_080697.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK079062, AK167575, BE995909
    Consensus CDS
    CCDS39183.1
    UniProtKB/Swiss-Prot
    Q3TGK8, Q3TXA2, Q3U8Y4, Q8BGB7, Q8VC92, Q9D6U4
    Related
    ENSMUSP00000129704.2, ENSMUST00000169390.8
    Conserved Domains (2) summary
    pfam13419
    Location:13 → 227
    HAD_2; Haloacid dehalogenase-like hydrolase
    cl21460
    Location:10 → 252
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_027990.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), and therefore is not thought to be protein-coding.
    Source sequence(s)
    AK079062, AK167575, BE995909, CX235072

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100186887..100216784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254776.2 → XP_030110636.1  enolase-phosphatase E1 isoform X2

    Conserved Domains (1) summary
    cd01629
    Location:1 → 146
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

  2. XM_030254775.2 → XP_030110635.1  enolase-phosphatase E1 isoform X2

    Conserved Domains (1) summary
    cd01629
    Location:1 → 146
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

  3. XM_036165444.1 → XP_036021337.1  enolase-phosphatase E1 isoform X2

    Conserved Domains (1) summary
    cd01629
    Location:1 → 146
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

  4. XM_011249550.4 → XP_011247852.1  enolase-phosphatase E1 isoform X1

    See identical proteins and their annotated locations for XP_011247852.1

    Conserved Domains (1) summary
    cd01629
    Location:12 → 239
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

  5. XM_006535190.3 → XP_006535253.1  enolase-phosphatase E1 isoform X1

    See identical proteins and their annotated locations for XP_006535253.1

    Conserved Domains (1) summary
    cd01629
    Location:12 → 239
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

  6. XM_006535189.4 → XP_006535252.1  enolase-phosphatase E1 isoform X1

    See identical proteins and their annotated locations for XP_006535252.1

    Conserved Domains (1) summary
    cd01629
    Location:12 → 239
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGB7.1 GenPept UniProtKB/Swiss-Prot:Q8BGB7

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