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Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 678759, updated on 26-Jun-2024

Summary

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Official Symbol
Ndufa10provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase subunit A10provided by RGD
Primary source
RGD:727968
See related
Ensembl:ENSRNOG00000016470 AllianceGenome:RGD:727968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ndufa10l
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex I. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 592.7), Muscle (RPKM 351.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufa10 in Genome Data Viewer
Location:
9q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (100454498..100490023, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93007034..93041825, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (99617051..99651827, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480416 Neighboring gene uncharacterized LOC108351974 Neighboring gene signal peptidase complex subunit 3, pseudogene 1 Neighboring gene olfactory receptor family 6 subfamily B member 2 Neighboring gene olfactory receptor family 6 subfamily B member 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of mitochondrial NADH dehydrogenase 1α subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension. Huang L, et al. Mol Med Rep, 2016 Jan. PMID 26648553
  2. [Comparative proteomic analysis of the prefrontal cortex between normal and heroin-addicted rats]. Qiu PM, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2007 Apr. PMID 17545021
  3. Isolation of diabetes-associated kidney genes using differential display. Page R, et al. Biochem Biophys Res Commun, 1997 Mar 6. PMID 9125149
  4. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Morais VA, et al. Science, 2014 Apr 11. PMID 24652937
  5. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ass spectrometric analysis revealed that the replacement of an aspartate residue with asparagine at amino acid position 120 was the biochemical difference between the two Ndufa10 isoforms
    Title: Characterization of mitochondrial NADH dehydrogenase 1α subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72603, MGC112575

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Names
CI-42kD
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10
NADH-ubiquinone oxidoreductase 42 kDa subunit
complex I-42kD
NP_955789.2
XP_008765607.1
XP_038940123.1
XP_063123776.1
XP_063123777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199495.4 → NP_955789.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor

    See identical proteins and their annotated locations for NP_955789.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q561S0, Q80WE0
    UniProtKB/TrEMBL
    A0A8L2QBL2, A6JQU0
    Related
    ENSRNOP00000022089.6, ENSRNOT00000022089.7
    Conserved Domains (1) summary
    cd02030
    Location:59 → 277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    100454498..100490023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267707.1 → XP_063123777.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q561S0, Q80WE0
    UniProtKB/TrEMBL
    A0A8L2QBL2, A6JQU0

  2. XM_063267706.1 → XP_063123776.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q561S0, Q80WE0
    UniProtKB/TrEMBL
    A0A8L2QBL2, A6JQU0

  3. XM_039084195.2 → XP_038940123.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6JQU3, Q6P6W6
    Conserved Domains (1) summary
    cd02030
    Location:1 → 195
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...

  4. XM_008767385.4 → XP_008765607.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6A5, A6JQU2
    Conserved Domains (1) summary
    cd02030
    Location:59 → 277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q561S0.1 GenPept UniProtKB/Swiss-Prot:Q561S0

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