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Tomm20 translocase of outer mitochondrial membrane 20 [ Mus musculus (house mouse) ]

Gene ID: 67952, updated on 28-Oct-2024

Summary

Official Symbol
Tomm20provided by MGI
Official Full Name
translocase of outer mitochondrial membrane 20provided by MGI
Primary source
MGI:MGI:1915202
See related
Ensembl:ENSMUSG00000093904 AllianceGenome:MGI:1915202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAS20; MOM19; TOM20; Gm19268; mKIAA0016; 1810060K07Rik
Summary
Predicted to enable mitochondrion targeting sequence binding activity; protein-transporting ATPase activity; and unfolded protein binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Located in migrasome; mitochondrial envelope; and sperm midpiece. Is active in cell periphery. Is expressed in several structures, including central nervous system; genitourinary system; heart; and liver. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 54.6), placenta adult (RPKM 33.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tomm20 in Genome Data Viewer
Location:
8 E2; 8 74.64 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (127657414..127672671, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (126930664..126945921, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129281926-129282079 Neighboring gene predicted gene 45805 Neighboring gene STARR-seq mESC enhancer starr_23071 Neighboring gene STARR-seq mESC enhancer starr_23074 Neighboring gene predicted gene, 31718 Neighboring gene VISTA enhancer mm1464 Neighboring gene STARR-positive B cell enhancer ABC_E2883 Neighboring gene STARR-seq mESC enhancer starr_23077 Neighboring gene RIKEN cDNA A630001O12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129371550-129371792 Neighboring gene STARR-positive B cell enhancer ABC_E5051 Neighboring gene STARR-positive B cell enhancer ABC_E6705 Neighboring gene STARR-positive B cell enhancer mm9_chr8:129391519-129391820 Neighboring gene STARR-positive B cell enhancer ABC_E6706 Neighboring gene STARR-positive B cell enhancer ABC_E6707 Neighboring gene predicted gene, 53208 Neighboring gene predicted gene, 26397 Neighboring gene RNA binding motif protein 34 Neighboring gene STARR-seq mESC enhancer starr_23083 Neighboring gene STARR-positive B cell enhancer ABC_E6708 Neighboring gene predicted gene, 29688

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6333, MGC117642

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mitochondrion targeting sequence binding IEA
Inferred from Electronic Annotation
more info
 
enables mitochondrion targeting sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-transporting ATPase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-transporting ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in migrasome IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial outer membrane translocase complex IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM20 homolog
Names
mitochondrial 20 kDa outer membrane protein
outer mitochondrial membrane receptor Tom20
translocase of outer mitochondrial membrane 20 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024214.2NP_077176.1  mitochondrial import receptor subunit TOM20 homolog

    See identical proteins and their annotated locations for NP_077176.1

    Status: VALIDATED

    Source sequence(s)
    AC119874, AK160168, DN174518
    Consensus CDS
    CCDS22786.1
    UniProtKB/Swiss-Prot
    Q9DCC8
    UniProtKB/TrEMBL
    Q4KL41
    Related
    ENSMUSP00000136493.2, ENSMUST00000179857.3
    Conserved Domains (1) summary
    TIGR00985
    Location:1127
    3a0801s04tom; mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    127657414..127672671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)