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Ldlrad4 low density lipoprotein receptor class A domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679578, updated on 17-Aug-2024

Summary

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Official Symbol
Ldlrad4provided by RGD
Official Full Name
low density lipoprotein receptor class A domain containing 4provided by RGD
Primary source
RGD:1587105
See related
EnsemblRapid:ENSRNOG00000016879 AllianceGenome:RGD:1587105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable R-SMAD binding activity. Predicted to be involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi membrane and early endosome membrane. Orthologous to human LDLRAD4 (low density lipoprotein receptor class A domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 56.2), Kidney (RPKM 51.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63789089..64118166)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61519253..61848403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63717423..64045224)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552297 Neighboring gene SEH1-like nucleoporin Neighboring gene centrosomal protein 192 Neighboring gene small nucleolar RNA SNORA33 Neighboring gene tubulin, alpha 1B, pseudogene 3 Neighboring gene uncharacterized LOC134482959 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 118 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 1 Neighboring gene family with sequence similarity 210, member A Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene melanocortin 5 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C18 ORF1, a novel negative regulator of transforming growth factor-β signaling. Nakano N, et al. J Biol Chem, 2014 May 2. PMID 24627487, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables R-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor class A domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271365.1 → NP_001258294.1  low-density lipoprotein receptor class A domain-containing protein 4

    See identical proteins and their annotated locations for NP_001258294.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    63789089..64118166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097102.2 → XP_038953030.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  2. XM_039097106.2 → XP_038953034.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  3. XM_039097104.2 → XP_038953032.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  4. XM_039097100.2 → XP_038953028.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Related
    ENSRNOP00000082880.1, ENSRNOT00000113866.2
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  5. XM_063277574.1 → XP_063133644.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

  6. XM_039097109.2 → XP_038953037.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  7. XM_063277575.1 → XP_063133645.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

  8. XM_039097101.2 → XP_038953029.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  9. XM_063277573.1 → XP_063133643.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6

  10. XM_039097105.2 → XP_038953033.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  11. XM_039097103.2 → XP_038953031.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  12. XM_039097098.2 → XP_038953026.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  13. XM_039097112.2 → XP_038953040.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  14. XM_039097107.2 → XP_038953035.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  15. XM_039097111.2 → XP_038953039.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  16. XM_039097110.2 → XP_038953038.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  17. XM_039097108.2 → XP_038953036.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUC8, A6IXW6
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  18. XM_039097117.2 → XP_038953045.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

    UniProtKB/TrEMBL
    A6IXW9

  19. XM_039097116.2 → XP_038953044.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  20. XM_039097113.2 → XP_038953041.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K955, A6IXW8, F1LZA8

  21. XM_063277576.1 → XP_063133646.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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