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Slc17a4 solute carrier family 17, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679784, updated on 2-Nov-2024

Summary

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Official Symbol
Slc17a4provided by RGD
Official Full Name
solute carrier family 17, member 4provided by RGD
Primary source
RGD:1584758
See related
EnsemblRapid:ENSRNOG00000022505 AllianceGenome:RGD:1584758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thyroid hormone transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in monoatomic anion transport and sodium-dependent phosphate transport. Predicted to be located in brush border membrane. Predicted to be active in apical plasma membrane. Orthologous to human SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 83.3) and Kidney (RPKM 39.9) See more
Orthologs
human mouse all
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Genomic context

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See Slc17a4 in Genome Data Viewer
Location:
17p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41629417..41646623)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41201546..41218752)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43452316..43472192)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909739 Neighboring gene H2A clustered histone 1 Neighboring gene H2B clustered histone 1 Neighboring gene solute carrier family 17 member 1 Neighboring gene uncharacterized LOC134482855 Neighboring gene solute carrier family 17 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in urate transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable small intestine urate exporter
Names
solute carrier family 17 (sodium phosphate), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271214.1 → NP_001258143.1  probable small intestine urate exporter

    See identical proteins and their annotated locations for NP_001258143.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2JXU5, A6KLJ0
    Related
    ENSRNOP00000056253.5, ENSRNOT00000059494.6
    Conserved Domains (1) summary
    cd17318
    Location:40 → 479
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    41629417..41646623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771658.3 → XP_008769880.1  probable small intestine urate exporter isoform X1

    See identical proteins and their annotated locations for XP_008769880.1

    UniProtKB/TrEMBL
    A0A0G2JXU5, A6KLJ0
    Related
    ENSRNOP00000070406.1, ENSRNOT00000088939.3
    Conserved Domains (1) summary
    cd17318
    Location:40 → 479
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. XM_039096055.1 → XP_038951983.1  probable small intestine urate exporter isoform X2

    UniProtKB/TrEMBL
    D3ZX83
    Conserved Domains (1) summary
    cl28910
    Location:40 → 401
    MFS; Major Facilitator Superfamily

  3. XM_039096054.2 → XP_038951982.1  probable small intestine urate exporter isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXU5, A6KLJ0
    Conserved Domains (1) summary
    cd17318
    Location:40 → 479
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  4. XM_008771659.4 → XP_008769881.1  probable small intestine urate exporter isoform X1

    See identical proteins and their annotated locations for XP_008769881.1

    UniProtKB/TrEMBL
    A0A0G2JXU5, A6KLJ0
    Conserved Domains (1) summary
    cd17318
    Location:40 → 479
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  5. XM_039096056.1 → XP_038951984.1  probable small intestine urate exporter isoform X3

    Conserved Domains (1) summary
    TIGR00894
    Location:12 → 293
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein Strain
Heading Accession and Version

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