Slc9b2 solute carrier family 9 member B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc9b2provided by RGD
Official Full Name: solute carrier family 9 member B2provided by RGD
Primary source: RGD:1598112
See related: AllianceGenome:RGD:1598112
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nhedc2
Summary: Predicted to enable identical protein binding activity; lithium:proton antiporter activity; and sodium:proton antiporter activity. Predicted to be involved in several processes, including flagellated sperm motility; regulation of insulin secretion involved in cellular response to glucose stimulus; and sodium ion transport. Predicted to act upstream of or within positive regulation of osteoclast development. Located in intracellular vesicle and mitochondrial inner membrane. Orthologous to human SLC9B2 (solute carrier family 9 member B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 16.5), Brain (RPKM 15.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (226400358..226435039)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (223726982..223761234)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (240485254..240519166)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lithium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lithium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
NOT located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 9B2

Names: Na+/H+ exchanger domain containing 2; mitochondrial sodium/hydrogen exchanger 9B2; mitochondrial sodium/hydrogen exchanger NHA2; solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; solute carrier family 9, subfamily B (cation proton antiporter 2), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109385.2 → NP_001102855.1 sodium/hydrogen exchanger 9B2

See identical proteins and their annotated locations for NP_001102855.1

Status: PROVISIONAL

Source sequence(s)

BC166815

UniProtKB/TrEMBL

B2RYK8

Conserved Domains (1) summary

cl01133
Location:176 → 534

Na_H_Exchanger; Sodium/hydrogen exchanger family