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Retreg3 reticulophagy regulator family member 3 [ Mus musculus (house mouse) ]

Gene ID: 67998, updated on 28-Oct-2024

Summary

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Official Symbol
Retreg3provided by MGI
Official Full Name
reticulophagy regulator family member 3provided by MGI
Primary source
MGI:MGI:1915248
See related
Ensembl:ENSMUSG00000017802 AllianceGenome:MGI:1915248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam134c; 1300010M03Rik; 4933404C01Rik
Summary
Enables endoplasmic reticulum-autophagosome adaptor activity. Acts upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RETREG3 (reticulophagy regulator family member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in mammary gland adult (RPKM 37.6), thymus adult (RPKM 37.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Retreg3 in Genome Data Viewer
Location:
11 D; 11 64.2 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100987148..101010720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101096322..101119841, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene Coenzyme A synthase Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene MAX-like protein X Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. Iavarone F, et al. EMBO Rep, 2024 Aug. PMID 39039299, Free PMC Article
  2. Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Di Lorenzo G, et al. Sci Adv, 2022 Sep 2. PMID 36044577, Free PMC Article
  3. Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. Reggio A, et al. EMBO Rep, 2021 Sep 6. PMID 34338405, Free PMC Article
  4. Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Kurth I, et al. Nat Genet, 2009 Nov. PMID 19838196
  5. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. Probert F, et al. J Proteome Res, 2015 May 1. PMID 25849460

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
    Title: Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endoplasmic reticulum-autophagosome adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within collagen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum tubular network organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within reticulophagy IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within reticulophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reticulophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
reticulophagy regulator 3
Names
family with sequence similarity 134, member C
protein FAM134C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361583.1 → NP_001348512.1  reticulophagy regulator 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX255926
    Conserved Domains (1) summary
    pfam02453
    Location:60 → 210
    Reticulon; Reticulon

  2. NM_026501.3 → NP_080777.1  reticulophagy regulator 3 isoform 1

    See identical proteins and their annotated locations for NP_080777.1

    Status: VALIDATED

    Source sequence(s)
    AK004979, AK051025, BX255926
    Consensus CDS
    CCDS25449.1
    UniProtKB/Swiss-Prot
    Q3TQL8, Q3U9Q7, Q8BQC4, Q922X3, Q9CQV4
    Related
    ENSMUSP00000017946.6, ENSMUST00000017946.6
    Conserved Domains (1) summary
    pfam02453
    Location:60 → 210
    Reticulon; Reticulon

  3. NM_028933.4 → NP_083209.1  reticulophagy regulator 3 isoform 2

    See identical proteins and their annotated locations for NP_083209.1

    Status: VALIDATED

    Source sequence(s)
    BX255926
    Consensus CDS
    CCDS25450.1
    UniProtKB/Swiss-Prot
    Q9CQV4
    Related
    ENSMUSP00000102916.4, ENSMUST00000107295.10

RNA

  1. NR_155070.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK004979, AK016648, AK051025, BX255926

  2. NR_155071.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK004979, AK051025, BX255926, CF726002

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100987148..101010720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156924.1 → XP_036012817.1  reticulophagy regulator 3 isoform X1

    Conserved Domains (1) summary
    cd22562
    Location:41 → 232
    RETR3_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQV4.1 GenPept UniProtKB/Swiss-Prot:Q9CQV4

Gene LinkOut

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