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Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680014, updated on 2-Nov-2024

Summary

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Official Symbol
Esco1provided by RGD
Official Full Name
establishment of sister chromatid cohesion N-acetyltransferase 1provided by RGD
Primary source
RGD:1596873
See related
EnsemblRapid:ENSRNOG00000014031 AllianceGenome:RGD:1596873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in mitotic sister chromatid cohesion; protein acetylation; and regulation of DNA replication. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 169.0), Spleen (RPKM 149.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Esco1 in Genome Data Viewer
Location:
18p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1904748..1959609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1630560..1686803, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1789796..1857271, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene GREB1 like retinoic acid receptor coactivator Neighboring gene heat shock protein family D (Hsp60) member 1 like 1 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 2 Neighboring gene protein RCC2-like Neighboring gene ATP synthase membrane subunit G like 4 Neighboring gene uncharacterized LOC134482900 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein D1 polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1. Rivera-Colón Y, et al. J Biol Chem, 2016 Dec 16. PMID 27803161, Free PMC Article
  2. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Kouznetsova E, et al. Structure, 2016 May 3. PMID 27112597
  3. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Hou F, et al. Mol Biol Cell, 2005 Aug. PMID 15958495, Free PMC Article
  4. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
  5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Nishiyama T, et al. Cell, 2010 Nov 24. PMID 21111234

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide-lysine-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetyltransferase ESCO1
Names
establishment of cohesion 1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126299.2 → NP_001119771.2  N-acetyltransferase ESCO1

    See identical proteins and their annotated locations for NP_001119771.2

    Status: VALIDATED

    Source sequence(s)
    BC166441
    UniProtKB/TrEMBL
    B2GUX2
    Related
    ENSRNOP00000032270.4, ENSRNOT00000033312.7
    Conserved Domains (2) summary
    pfam13878
    Location:604 → 643
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:763 → 831
    Acetyltransf_13; ESCO1/2 acetyl-transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    1904748..1959609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277580.1 → XP_063133650.1  N-acetyltransferase ESCO1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y5R8
    Related
    ENSRNOP00000079439.2, ENSRNOT00000100138.2

  2. XM_063277581.1 → XP_063133651.1  N-acetyltransferase ESCO1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y5R8

  3. XM_063277582.1 → XP_063133652.1  N-acetyltransferase ESCO1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y5R8

  4. XM_039097119.2 → XP_038953047.1  N-acetyltransferase ESCO1 isoform X2

    Related
    ENSRNOP00000076410.2, ENSRNOT00000118344.2
    Conserved Domains (1) summary
    pfam13880
    Location:719 → 787
    Acetyltransf_13; ESCO1/2 acetyl-transferase

  5. XM_063277577.1 → XP_063133647.1  N-acetyltransferase ESCO1 isoform X1

    UniProtKB/TrEMBL
    B2GUX2

  6. XM_039097120.2 → XP_038953048.1  N-acetyltransferase ESCO1 isoform X3

    Conserved Domains (1) summary
    pfam13878
    Location:604 → 643
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

  7. XM_063277578.1 → XP_063133648.1  N-acetyltransferase ESCO1 isoform X4

  8. XM_063277579.1 → XP_063133649.1  N-acetyltransferase ESCO1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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