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Grhpr glyoxylate and hydroxypyruvate reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 680021, updated on 19-Sep-2024

Summary

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Official Symbol
Grhprprovided by RGD
Official Full Name
glyoxylate and hydroxypyruvate reductaseprovided by RGD
Primary source
RGD:1308851
See related
EnsemblRapid:ENSRNOG00000012794 AllianceGenome:RGD:1308851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables carboxylic acid binding activity; nucleotide binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1452.3), Liver (RPKM 1445.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Grhpr in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64029856..64039287)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59234179..59243614)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60528981..60538410)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487064 Neighboring gene uncharacterized LOC120102863 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene uncharacterized LOC134486934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coenzyme specificity of mammalian liver D-glycerate dehydrogenase. Van Schaftingen E, et al. Eur J Biochem, 1989 Dec 8. PMID 2689175
  2. A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. Takayama T, et al. Nephrol Dial Transplant, 2007 Aug. PMID 17510093, Free PMC Article
  3. Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth MP, et al. J Mol Biol, 2006 Jun 30. PMID 16756993
  4. Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. Rumsby G, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524214
  5. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Cramer SD, et al. Hum Mol Genet, 1999 Oct. PMID 10484776

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxylate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glyoxylate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroxypyruvate reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxypyruvate reductase (NADH) activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroxypyruvate reductase [NAD(P)H] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxypyruvate reductase [NAD(P)H] activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dicarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glyoxylate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
NP_001107226.1
XP_017449109.1
XP_017449110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113754.1 → NP_001107226.1  glyoxylate reductase/hydroxypyruvate reductase

    See identical proteins and their annotated locations for NP_001107226.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473962
    UniProtKB/TrEMBL
    A0A8J8XIM5, B0BN46, E9PSJ6
    Related
    ENSRNOP00000046867.5, ENSRNOT00000051445.8
    Conserved Domains (1) summary
    cd05301
    Location:14 → 326
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    64029856..64039287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593621.3 → XP_017449110.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:1 → 174
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_017593620.2 → XP_017449109.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:1 → 174
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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