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Gas2l3 growth arrest-specific 2 like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680280, updated on 2-Nov-2024

Summary

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Symbol
Gas2l3provided by RGD
Full Name
growth arrest-specific 2 like 3provided by RGD
Primary source
RGD:1594151
See related
EnsemblRapid:ENSRNOG00000063755 AllianceGenome:RGD:1594151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and microtubule binding activity. Predicted to be involved in actin crosslink formation and microtubule cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Predicted to be located in actin cytoskeleton and microtubule cytoskeleton. Predicted to be active in actin filament. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 32.1), Thymus (RPKM 17.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gas2l3 in Genome Data Viewer
Location:
7q13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (25690929..25726806, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (23803578..23836816, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29963129..29996021, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene Annexin A7, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins. Stroud MJ, et al. J Biol Chem, 2011 Jul 15. PMID 21561867, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GAS2-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432020.1 → NP_001418949.1  GAS2-like protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AL26

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    25690929..25726806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595199.3 → XP_017450688.1  GAS2-like protein 3

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_008765306.4 → XP_008763528.1  GAS2-like protein 3

    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  3. XM_008765308.4 → XP_008763530.1  GAS2-like protein 3

    See identical proteins and their annotated locations for XP_008763530.1

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  4. XM_017595198.3 → XP_017450687.1  GAS2-like protein 3

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  5. XM_039080081.2 → XP_038936009.1  GAS2-like protein 3

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  6. XM_063264406.1 → XP_063120476.1  GAS2-like protein 3

    UniProtKB/TrEMBL
    A0A8I6AL26
    Related
    ENSRNOP00000094564.1, ENSRNOT00000120268.2

  7. XM_001056437.8 → XP_001056437.2  GAS2-like protein 3

    See identical proteins and their annotated locations for XP_001056437.2

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily

  8. XM_006241237.5 → XP_006241299.1  GAS2-like protein 3

    See identical proteins and their annotated locations for XP_006241299.1

    UniProtKB/TrEMBL
    A0A8I6AL26
    Conserved Domains (3) summary
    PHA03247
    Location:306 → 645
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:46 → 174
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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