Rnf146 ring finger protein 146 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf146provided by MGI
Official Full Name: ring finger protein 146provided by MGI
Primary source: MGI:MGI:1915281
See related: Ensembl:ENSMUSG00000038876 AllianceGenome:MGI:1915281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iduna; 2610509H23Rik
Summary: Predicted to enable enzyme binding activity; poly-ADP-D-ribose binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of canonical Wnt signaling pathway; and protein ubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Used to study osteochondrodysplasia. Orthologous to human RNF146 (ring finger protein 146). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 13.4), CNS E14 (RPKM 12.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 16.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (29220172..29238438, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (29344176..29362442, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Title: PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Dysregulation of the Wnt/beta-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder.
Title: Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder.
The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway.
Title: The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway.
Iduna might prevent TBI by specifically inhibiting parthanatos and promoting mitochondrial function, with the p53-MDM2 pathway playing a critical role.
Title: Iduna protects HT22 cells by inhibiting parthanatos: The role of the p53-MDM2 pathway.
Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression.
Title: Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
These findings indicate that RNF146 is required to coordinate beta-catenin signaling within the osteoblast lineage during embryonic and postnatal bone development
Title: Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inhibitory element in the RNF146 promoter.
Title: RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported.
Title: The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes
Title: Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes.
Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system.
Title: Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU015485 (e-PCR)
- UniSTS:167028

BF389128 (e-PCR)
- UniSTS:245382

AI314462 (e-PCR)
- UniSTS:159965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF146

Names: RING-type E3 ubiquitin transferase RNF146

NP_001103666.1

EC 2.3.2.27

NP_001103667.1

EC 2.3.2.27

NP_001103668.1

EC 2.3.2.27

NP_001271208.1

EC 2.3.2.27

NP_080794.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110196.1 → NP_001103666.1 E3 ubiquitin-protein ligase RNF146

See identical proteins and their annotated locations for NP_001103666.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AK012080, AK035665, BC050795, BF461810, BQ713250

Consensus CDS

CCDS48529.1

UniProtKB/Swiss-Prot

E0CX97, Q3TF93, Q3U6Y7, Q9CZW6

Related

ENSMUSP00000124215.2, ENSMUST00000160372.9

Conserved Domains (2) summary

smart00678
Location:105 → 177

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:37 → 79

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001110197.1 → NP_001103667.1 E3 ubiquitin-protein ligase RNF146

See identical proteins and their annotated locations for NP_001103667.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.

Source sequence(s)

AK035665, BC050795, BF461810, BQ713250, BY787516

Consensus CDS

CCDS48529.1

UniProtKB/Swiss-Prot

E0CX97, Q3TF93, Q3U6Y7, Q9CZW6

Related

ENSMUSP00000037224.5, ENSMUST00000037548.11

Conserved Domains (2) summary

smart00678
Location:105 → 177

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:37 → 79

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001110198.1 → NP_001103668.1 E3 ubiquitin-protein ligase RNF146

See identical proteins and their annotated locations for NP_001103668.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AK035665, BC050795, BF461810, BQ713250, BU562186

Consensus CDS

CCDS48529.1

UniProtKB/Swiss-Prot

E0CX97, Q3TF93, Q3U6Y7, Q9CZW6

Conserved Domains (2) summary

smart00678
Location:105 → 177

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:37 → 79

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001284279.1 → NP_001271208.1 E3 ubiquitin-protein ligase RNF146

See identical proteins and their annotated locations for NP_001271208.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AC153912, AK012080, AK016748, BF461810

Consensus CDS

CCDS48529.1

UniProtKB/Swiss-Prot

E0CX97, Q3TF93, Q3U6Y7, Q9CZW6

Related

ENSMUSP00000124772.2, ENSMUST00000162335.8

Conserved Domains (2) summary

smart00678
Location:105 → 177

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:37 → 79

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_026518.4 → NP_080794.2 E3 ubiquitin-protein ligase RNF146

See identical proteins and their annotated locations for NP_080794.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate splice site and also lacks an exon in the 5' UTR, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AK035665, BC050795, BF461810, BQ713250

Consensus CDS

CCDS48529.1

UniProtKB/Swiss-Prot

E0CX97, Q3TF93, Q3U6Y7, Q9CZW6

Related

ENSMUSP00000124288.2, ENSMUST00000160144.9

Conserved Domains (2) summary

smart00678
Location:105 → 177

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:37 → 79

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...