Hist1h2bc histone cluster 1, H2bc [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hist1h2bcprovided by RGD
Full Name: histone cluster 1, H2bcprovided by RGD
Primary source: RGD:1591796
See related: AllianceGenome:RGD:1591796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hist1h2bcl1
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and innate immune response in mucosa. Predicted to be located in cytosol; extracellular space; and nucleoplasm. Predicted to be part of nucleosome. Orthologous to several human genes including H2BC10 (H2B clustered histone 10); H2BC4 (H2B clustered histone 4); and H2BC5 (H2B clustered histone 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 17p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (47388085..47392349, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (42692335..42696601, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (44736184..44738393, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

Hist1h2bc (e-PCR), detects polymorphism
- UniSTS:259084

UniSTS:487787 (e-PCR)
- UniSTS:487787

UniSTS:488585 (e-PCR)
- UniSTS:488585

UniSTS:493006 (e-PCR)
- UniSTS:493006

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone cluster 1, H2bc

Names: histone H2B type 1; histone H2B type 1-C/E/F/G/I; histone cluster 1 H2B family member C like 1; histone cluster 1, H2bc-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.