Chd1l chromodomain helicase DNA binding protein 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chd1lprovided by MGI
Official Full Name: chromodomain helicase DNA binding protein 1-likeprovided by MGI
Primary source: MGI:MGI:1915308
See related: Ensembl:ENSMUSG00000028089 AllianceGenome:MGI:1915308
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Alc1; Snf2p; 4432404A22Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; histone reader activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus and site of double-strand break. Is expressed in genitourinary system and liver. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in testis adult (RPKM 13.9), bladder adult (RPKM 9.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 42.17 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (97468056..97517538, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (97560740..97610222, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Title: Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
overexpression of CHD1L in embryonic cells upregulated the expression of ectoderm genes, especially PAX6
Title: CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
found a significant correlation of CHD1L with developmental transcriptional factors and lineage differentiation markers in clinical hepatocellular carcinoma patients
Title: CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.
these results identify CHD1L as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells.
Title: CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming.
TRIM33 plays a role in PARP-dependent DNA damage response and regulates ALC1 activity by promoting its timely removal from sites of DNA damage.
Title: Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
Title: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
our data strongly support that CHD1L is a novel oncogene and plays an important role in hepatocellular carcinoma pathogenesis
Title: Transgenic CHD1L expression in mouse induces spontaneous tumors.
Reports that transgenic CHD1L (Alc1) expression induces spontaneous tumors in mice.
Title: Transgenic CHD1L expression in mouse induces spontaneous tumors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent chromatin remodeler activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent chromatin remodeler activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chromodomain-helicase-DNA-binding protein 1-like

Names: amplified in liver cancer 1

NP_001405749.1

EC 3.6.4.12

NP_080815.1

EC 3.6.4.12

XP_017175190.1

EC 3.6.4.12

XP_036019152.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418820.1 → NP_001405749.1 chromodomain-helicase-DNA-binding protein 1-like isoform 2

Status: VALIDATED

Source sequence(s)

AC140839
NM_026539.3 → NP_080815.1 chromodomain-helicase-DNA-binding protein 1-like isoform 1

See identical proteins and their annotated locations for NP_080815.1

Status: VALIDATED

Source sequence(s)

AC140839

Consensus CDS

CCDS38561.1

UniProtKB/Swiss-Prot

Q3TMX1, Q6P5C0, Q9CXF7

Related

ENSMUSP00000029730.5, ENSMUST00000029730.5

Conserved Domains (4) summary

cd00046
Location:59 → 199

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd03331
Location:721 → 871

Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...

pfam00176
Location:43 → 322

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:340 → 453

Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

97468056..97517538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163259.1 → XP_036019152.1 chromodomain-helicase-DNA-binding protein 1-like isoform X3

Conserved Domains (1) summary

PLN03142
Location:39 → 549

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
XM_017319701.3 → XP_017175190.1 chromodomain-helicase-DNA-binding protein 1-like isoform X2

Conserved Domains (1) summary

PLN03142
Location:39 → 549

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional