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Tm9sf2 transmembrane 9 superfamily member 2 [ Mus musculus (house mouse) ]

Gene ID: 68059, updated on 2-Nov-2024

Summary

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Official Symbol
Tm9sf2provided by MGI
Official Full Name
transmembrane 9 superfamily member 2provided by MGI
Primary source
MGI:MGI:1915309
See related
Ensembl:ENSMUSG00000025544 AllianceGenome:MGI:1915309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P76; D14Ertd64e; 1500001N15Rik
Summary
Predicted to be involved in protein localization to membrane; regulation of heparan sulfate proteoglycan biosynthetic process; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. Is expressed in several structures, including brain; cranium; eye; hemolymphoid system gland; and liver. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 91.0), duodenum adult (RPKM 80.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tm9sf2 in Genome Data Viewer
Location:
14 E5; 14 65.86 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122342290..122397015)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122107082..122159603)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ubiquitin associated domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122364300-122364601 Neighboring gene G protein-coupled receptor 183 Neighboring gene STARR-positive B cell enhancer ABC_E8580 Neighboring gene STARR-positive B cell enhancer ABC_E4126 Neighboring gene STARR-positive B cell enhancer ABC_E4127 Neighboring gene STARR-positive B cell enhancer ABC_E8581 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene STARR-positive B cell enhancer ABC_E5466 Neighboring gene RIKEN cDNA A330035P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5467 Neighboring gene STARR-seq mESC enhancer starr_37749 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene citrate lyase beta like Neighboring gene STARR-seq mESC enhancer starr_37753 Neighboring gene STARR-seq mESC enhancer starr_37767 Neighboring gene predicted gene 5089 Neighboring gene predicted gene, 25464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative analysis of the expression patterns of TM9SF family members in mice. Zhao R, et al. Gene Expr Patterns, 2024 Jun. PMID 38719197
  2. Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Orelio C, et al. Blood, 2003 Mar 15. PMID 12433684
  3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane 9 superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080556.3 → NP_542123.3  transmembrane 9 superfamily member 2 precursor

    See identical proteins and their annotated locations for NP_542123.3

    Status: VALIDATED

    Source sequence(s)
    AK048012, AV028818, BB619330
    Consensus CDS
    CCDS27345.1
    UniProtKB/Swiss-Prot
    P58021
    UniProtKB/TrEMBL
    Q542E4, Q8C6H4, Q8C7F9
    Related
    ENSMUSP00000026624.5, ENSMUST00000026624.11
    Conserved Domains (1) summary
    pfam02990
    Location:74 → 618
    EMP70; Endomembrane protein 70

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    122342290..122397015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158835.1 → XP_036014728.1  transmembrane 9 superfamily member 2 isoform X1

    UniProtKB/Swiss-Prot
    P58021
    UniProtKB/TrEMBL
    Q542E4, Q8C6H4, Q8C7F9
    Conserved Domains (1) summary
    pfam02990
    Location:74 → 618
    EMP70; Endomembrane protein 70
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58021.1 GenPept UniProtKB/Swiss-Prot:P58021

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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