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Rbms3 RNA binding motif, single stranded interacting protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680726, updated on 2-Nov-2024

Summary

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Official Symbol
Rbms3provided by RGD
Official Full Name
RNA binding motif, single stranded interacting protein 3provided by RGD
Primary source
RGD:1588240
See related
EnsemblRapid:ENSRNOG00000025881 AllianceGenome:RGD:1588240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be involved in defense response to tumor cell; negative regulation of canonical Wnt signaling pathway; and regulation of gene expression. Predicted to act upstream of or within positive regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Orthologous to human RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 136.6), Kidney (RPKM 119.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbms3 in Genome Data Viewer
Location:
8q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (125183311..125970239, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (116305227..117625730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (124833804..125645895, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094286 Neighboring gene uncharacterized LOC134480244 Neighboring gene uncharacterized LOC120094352 Neighboring gene uncharacterized LOC134480245 Neighboring gene uncharacterized LOC102550774 Neighboring gene voltage-dependent anion channel 2, pseudogene 5 Neighboring gene uncharacterized LOC108351793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells. Yang Y, et al. Oncol Res, 2018 Jan 19. PMID 28409548, Free PMC Article
  2. Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins. Penkov D, et al. Gene, 2000 Feb 8. PMID 10675610
  3. Rbms3, an RNA-binding protein, mediates the expression of Ptf1a by binding to its 3'UTR during mouse pancreas development. Lu CK, et al. DNA Cell Biol, 2012 Jul. PMID 22372950
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif, single-stranded-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401889.1 → NP_001388818.1  RNA-binding motif, single-stranded-interacting protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6GDD6
    Related
    ENSRNOP00000039967.7, ENSRNOT00000041548.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    125183311..125970239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596208.3 → XP_017451697.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X10

  2. XM_017596203.3 → XP_017451692.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X5

    Related
    ENSRNOP00000029127.7, ENSRNOT00000036672.8

  3. XM_039082840.2 → XP_038938768.2  RNA-binding motif, single-stranded-interacting protein 3 isoform X7

  4. XM_017596202.3 → XP_017451691.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X4

  5. XM_017596201.3 → XP_017451690.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X3

  6. XM_017596199.3 → XP_017451688.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X1

    Related
    ENSRNOP00000094964.2, ENSRNOT00000117887.2

  7. XM_063266128.1 → XP_063122198.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X20

  8. XM_063266125.1 → XP_063122195.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X16

  9. XM_063266124.1 → XP_063122194.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X15

  10. XM_063266122.1 → XP_063122192.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X8

  11. XM_063266126.1 → XP_063122196.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X17

  12. XM_039082842.2 → XP_038938770.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X11

    UniProtKB/TrEMBL
    A6I3S8
    Related
    ENSRNOP00000085414.2, ENSRNOT00000098379.2
    Conserved Domains (2) summary
    cd12475
    Location:134 → 221
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:52 → 131
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

  13. XM_001061329.8 → XP_001061329.2  RNA-binding motif, single-stranded-interacting protein 3 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZJM8, A6I3S9, A6I3T0
    Related
    ENSRNOP00000077991.1, ENSRNOT00000094447.2
    Conserved Domains (2) summary
    cd12475
    Location:134 → 221
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:51 → 134
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. XM_063266127.1 → XP_063122197.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X19

  15. XM_017596207.3 → XP_017451696.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZMK2, A6I3T0
    Related
    ENSRNOP00000079325.1, ENSRNOT00000095366.2

  16. XM_039082844.2 → XP_038938772.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X14

    UniProtKB/TrEMBL
    A6I3T0
    Conserved Domains (2) summary
    cd12475
    Location:112 → 199
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:30 → 109
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

  17. XM_063266123.1 → XP_063122193.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X14

    Related
    ENSRNOP00000041726.7, ENSRNOT00000039904.8

  18. XM_039082845.2 → XP_038938773.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X18

    UniProtKB/TrEMBL
    A6I3T0
    Conserved Domains (2) summary
    cd12475
    Location:100 → 187
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:18 → 97
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

  19. XM_039082846.2 → XP_038938774.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X21

    Conserved Domains (2) summary
    TIGR01628
    Location:3 → 182
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12475
    Location:9 → 96
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

  20. XM_039082847.2 → XP_038938775.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X22

    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 162
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 76
    RRM_SF; RNA recognition motif (RRM) superfamily

  21. XM_063266129.1 → XP_063122199.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X22

  22. XM_017596206.3 → XP_017451695.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X6

  23. XM_017596200.3 → XP_017451689.3  RNA-binding motif, single-stranded-interacting protein 3 isoform X2

  24. XM_006244039.5 → XP_006244101.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X13

    UniProtKB/TrEMBL
    A6I3S8
    Conserved Domains (2) summary
    cd12475
    Location:134 → 221
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:51 → 134
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
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