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Eppk1 epiplakin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680860, updated on 2-Nov-2024

Summary

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Symbol
Eppk1provided by RGD
Full Name
epiplakin 1provided by RGD
Primary source
RGD:1587023
See related
EnsemblRapid:ENSRNOG00000068431 AllianceGenome:RGD:1587023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eppk1-ps1
Summary
Predicted to enable keratin filament binding activity. Predicted to be involved in several processes, including intermediate filament bundle assembly; negative regulation of keratinocyte migration; and regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including apicolateral plasma membrane; hemidesmosome; and keratin filament. Orthologous to human EPPK1 (epiplakin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 92.2), Heart (RPKM 51.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eppk1 in Genome Data Viewer
Location:
7q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109697607..109718468, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107816919..107842946, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117163383..117173741, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548315 Neighboring gene poly-U binding splicing factor 60 Neighboring gene nuclear receptor binding protein 2 Neighboring gene uncharacterized LOC134479927 Neighboring gene dystonin like 1 Neighboring gene uncharacterized LOC102548374

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of epiplakin-knockdown in cultured corneal epithelial cells. Kokado M, et al. BMC Res Notes, 2016 May 20. PMID 27206504, Free PMC Article
  2. Epiplakin modifies the motility of the HeLa cells and accumulates at the outer surfaces of 3-D cell clusters. Shimada H, et al. J Dermatol, 2013 Apr. PMID 23398049
  3. Epiplakin accelerates the lateral organization of keratin filaments during wound healing. Ishikawa K, et al. J Dermatol Sci, 2010 Nov. PMID 20926261
  4. Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice. Goto M, et al. Mol Cell Biol, 2006 Jan. PMID 16382146, Free PMC Article
  5. Increased fragility, impaired differentiation, and acceleration of migration of corneal epithelium of epiplakin-null mice. Kokado M, et al. Invest Ophthalmol Vis Sci, 2013 May 1. PMID 23599337

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables intermediate filament binding ISO
Inferred from Sequence Orthology
more info
  
enables keratin filament binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell proliferation involved in wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelium regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  
located_in perinucleolar compartment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epiplakin
Names
epiplakin 1, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398964.1 → NP_001385893.1  epiplakin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000093639.2, ENSRNOT00000109637.2
    Conserved Domains (2) summary
    smart00250
    Location:1648 → 1685
    PLEC; Plectin repeat
    pfam00681
    Location:2860 → 2899
    Plectin; Plectin repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109697607..109718468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials