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Ociad1 OCIA domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68095, updated on 28-Oct-2024

Summary

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Official Symbol
Ociad1provided by MGI
Official Full Name
OCIA domain containing 1provided by MGI
Primary source
MGI:MGI:1915345
See related
Ensembl:ENSMUSG00000029152 AllianceGenome:MGI:1915345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emi2; Imi2; OCIA; Asrij; TPA018; 6030432N09Rik; B230209J16Rik
Summary
Involved in regulation of stem cell differentiation. Located in endosome. Is expressed in several structures, including cardiovascular system; early conceptus; gonad; limb bud; and trunk mesenchyme. Orthologous to human OCIAD1 (OCIA domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 27.0), frontal lobe adult (RPKM 24.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ociad1 in Genome Data Viewer
Location:
5 C3.2; 5 38.44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73450093..73471420)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73292769..73314077)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700025M24 gene Neighboring gene STARR-seq mESC enhancer starr_13383 Neighboring gene predicted gene, 40316 Neighboring gene STARR-seq mESC enhancer starr_13384 Neighboring gene OCIA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13385 Neighboring gene predicted gene, 34496

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Embryonic stem cell and tissue-specific expression of a novel conserved gene, asrij. Mukhopadhyay A, et al. Dev Dyn, 2003 Aug. PMID 12889067
  2. OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages. Li X, et al. EBioMedicine, 2020 Jan. PMID 31931285, Free PMC Article
  3. Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Sinha S, et al. Blood, 2019 May 30. PMID 30952670
  4. Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency. Sinha A, et al. Cell Rep, 2013 Aug 29. PMID 23972987, Free PMC Article
  5. Identification of novel genes expressed during metanephric induction through single-cell library screening. Abidari JM, et al. Kidney Int, 2000 Jun. PMID 10844592

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
    Title: OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
  2. Asrij sequesters CSN5 via its conserved OCIA domain, thereby preventing p53 degradation.
    Title: Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.
  3. Asrij regulates mouse embryonic stem cell pluripotency via JAK/STAT signaling.
    Title: Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
  4. Asrij is expressed predominantly in mouse embryonic blood vessels; a splice variant is expressed in the brain, and can serve as an early stem cell marker.
    Title: Embryonic stem cell and tissue-specific expression of a novel conserved gene, asrij.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
OCIA domain-containing protein 1
Names
expressed during mesenchymal induction 2
induced during mesenchymal induction 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159887.1 → NP_001153359.1  OCIA domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001153359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK077904, AK078102, CX238085
    Consensus CDS
    CCDS80300.1
    UniProtKB/Swiss-Prot
    Q9CRD0
    Related
    ENSMUSP00000144515.2, ENSMUST00000200935.4
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  2. NM_001159888.1 → NP_001153360.1  OCIA domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001153360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AK077904, AK078102, CX238454
    Consensus CDS
    CCDS51518.1
    UniProtKB/Swiss-Prot
    Q9CRD0
    Related
    ENSMUSP00000069412.7, ENSMUST00000071081.13
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  3. NM_001159889.1 → NP_001153361.1  OCIA domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001153361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has a distinct 3' terminus, compared to variant 1, which results in a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC108828, AK078102
    Consensus CDS
    CCDS51518.1
    UniProtKB/Swiss-Prot
    Q9CRD0
    Related
    ENSMUSP00000128805.2, ENSMUST00000166823.5
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  4. NM_023429.4 → NP_075918.1  OCIA domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_075918.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK077904, AK078102
    Consensus CDS
    CCDS19339.1
    UniProtKB/Swiss-Prot
    Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
    Related
    ENSMUSP00000031038.5, ENSMUST00000031038.11
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73450093..73471420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165449.1 → XP_036021342.1  OCIA domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  2. XM_030254780.2 → XP_030110640.1  OCIA domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  3. XM_017321083.3 → XP_017176572.1  OCIA domain-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9CRD0
    Related
    ENSMUSP00000143799.2, ENSMUST00000202250.4
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  4. XM_017321082.2 → XP_017176571.1  OCIA domain-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9CRD0
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  5. XM_036165451.1 → XP_036021344.1  OCIA domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  6. XM_036165450.1 → XP_036021343.1  OCIA domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  7. XM_030254779.2 → XP_030110639.1  OCIA domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  8. XM_006504075.4 → XP_006504138.1  OCIA domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006504138.1

    UniProtKB/Swiss-Prot
    Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  9. XM_030254778.2 → XP_030110638.2  OCIA domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  10. XM_036165453.1 → XP_036021346.1  OCIA domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  11. XM_036165455.1 → XP_036021348.1  OCIA domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  12. XM_036165454.1 → XP_036021347.1  OCIA domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  13. XM_036165452.1 → XP_036021345.1  OCIA domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  14. XM_006504076.5 → XP_006504139.1  OCIA domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006504139.1

    UniProtKB/Swiss-Prot
    Q3TEC2, Q3TJS3, Q7TNB3, Q922M2, Q9CRD0
    Conserved Domains (1) summary
    pfam07051
    Location:24 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

RNA

  1. XR_376823.5 RNA Sequence

  2. XR_001784740.3 RNA Sequence

  3. XR_003955702.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRD0.1 GenPept UniProtKB/Swiss-Prot:Q9CRD0

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