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Ddhd2 DDHD domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680971, updated on 17-Aug-2024

Summary

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Official Symbol
Ddhd2provided by RGD
Official Full Name
DDHD domain containing 2provided by RGD
Primary source
RGD:1585818
See related
EnsemblRapid:ENSRNOG00000015501 AllianceGenome:RGD:1585818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phospholipase activity and triglyceride lipase activity. Predicted to act upstream of or within lipid droplet organization; positive regulation of mitochondrial fission; and triglyceride catabolic process. Predicted to be located in centriolar satellite; cytosol; and membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 207.0), Adrenal (RPKM 166.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73022136..73051746)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66319469..66349025)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71090096..71120713)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene BAG cochaperone 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482516 Neighboring gene phospholipid phosphatase 5 Neighboring gene nuclear receptor binding SET domain protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. Araki M, et al. J Biochem, 2016 Nov. PMID 27198176
  2. Protein purification and cloning of diacylglycerol lipase from rat brain. Aso C, et al. J Biochem, 2016 Jun. PMID 26790472, Free PMC Article
  3. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Inloes JM, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25267624, Free PMC Article
  4. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. Baba T, et al. J Biol Chem, 2014 Apr 18. PMID 24599962, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of visual learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipase DDHD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318416.1 → NP_001305345.1  phospholipase DDHD2

    Status: PROVISIONAL

    Source sequence(s)
    AB914679
    UniProtKB/TrEMBL
    A0A8I6AUM0, D3ZJ91
    Conserved Domains (4) summary
    smart00454
    Location:386 → 445
    SAM; Sterile alpha motif
    pfam02825
    Location:42 → 112
    WWE; WWE domain
    pfam02862
    Location:487 → 687
    DDHD; DDHD domain
    cl15755
    Location:379 → 447
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    73022136..73051746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001059724.8 → XP_001059724.3  phospholipase DDHD2 isoform X1

    See identical proteins and their annotated locations for XP_001059724.3

    UniProtKB/TrEMBL
    A0A8I6AUM0, D3ZJ91
    Conserved Domains (4) summary
    smart00454
    Location:386 → 445
    SAM; Sterile alpha motif
    pfam02825
    Location:42 → 112
    WWE; WWE domain
    pfam02862
    Location:487 → 687
    DDHD; DDHD domain
    cl15755
    Location:379 → 447
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_006253339.5 → XP_006253401.1  phospholipase DDHD2 isoform X1

    See identical proteins and their annotated locations for XP_006253401.1

    UniProtKB/TrEMBL
    A0A8I6AUM0, D3ZJ91
    Related
    ENSRNOP00000020832.8, ENSRNOT00000020832.10
    Conserved Domains (4) summary
    smart00454
    Location:386 → 445
    SAM; Sterile alpha motif
    pfam02825
    Location:42 → 112
    WWE; WWE domain
    pfam02862
    Location:487 → 687
    DDHD; DDHD domain
    cl15755
    Location:379 → 447
    SAM_superfamily; SAM (Sterile alpha motif )

  3. XM_063275720.1 → XP_063131790.1  phospholipase DDHD2 isoform X2

    UniProtKB/TrEMBL
    D3ZJ91
    Related
    ENSRNOP00000096096.2, ENSRNOT00000117689.2

  4. XM_008771368.3 → XP_008769590.1  phospholipase DDHD2 isoform X2

    See identical proteins and their annotated locations for XP_008769590.1

    UniProtKB/TrEMBL
    D3ZJ91
    Related
    ENSRNOP00000105009.1, ENSRNOT00000163681.1
    Conserved Domains (4) summary
    smart00454
    Location:386 → 445
    SAM; Sterile alpha motif
    pfam02825
    Location:42 → 112
    WWE; WWE domain
    pfam02862
    Location:470 → 670
    DDHD; DDHD domain
    cl15755
    Location:379 → 447
    SAM_superfamily; SAM (Sterile alpha motif )

  5. XM_039094820.2 → XP_038950748.1  phospholipase DDHD2 isoform X3

    UniProtKB/TrEMBL
    D3ZJ91
    Conserved Domains (3) summary
    pfam02825
    Location:44 → 112
    WWE; WWE domain
    pfam02862
    Location:487 → 672
    DDHD; DDHD domain
    cl15755
    Location:379 → 447
    SAM_superfamily; SAM (Sterile alpha motif )

  6. XM_063275721.1 → XP_063131791.1  phospholipase DDHD2 isoform X4

    UniProtKB/TrEMBL
    D3ZJ91

  7. XM_006253338.4 → XP_006253400.1  phospholipase DDHD2 isoform X5

    See identical proteins and their annotated locations for XP_006253400.1

    UniProtKB/TrEMBL
    D3ZJ91
    Conserved Domains (3) summary
    smart00454
    Location:290 → 349
    SAM; Sterile alpha motif
    pfam02862
    Location:391 → 591
    DDHD; DDHD domain
    cl15755
    Location:283 → 351
    SAM_superfamily; SAM (Sterile alpha motif )

RNA

  1. XR_005494673.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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