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Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68119, updated on 2-Nov-2024

Summary

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Official Symbol
Cmtm3provided by MGI
Official Full Name
CKLF-like MARVEL transmembrane domain containing 3provided by MGI
Primary source
MGI:MGI:2447162
See related
Ensembl:ENSMUSG00000031875 AllianceGenome:MGI:2447162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BNAS2; Cklfsf3; 9430096L06Rik
Summary
Predicted to enable cytokine activity. Acts upstream of or within blastocyst hatching and positive regulation of B cell receptor signaling pathway. Located in cytoplasm and nuclear membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human CMTM3 (CKLF like MARVEL transmembrane domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 59.8), adrenal adult (RPKM 43.1) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Cmtm3 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105065993..105074304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104339383..104347672)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45710 Neighboring gene CKLF-like MARVEL transmembrane domain containing 2B Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene STARR-positive B cell enhancer ABC_E11745

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CMTM3 Suppresses Proliferation and Osteogenic Transdifferentiation of C2C12 Myoblasts through p53 Upregulation. Shen E, et al. Cells, 2024 Aug 14. PMID 39195242, Free PMC Article
  2. CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling. Ye J, et al. Biochem Biophys Res Commun, 2023 Jul 30. PMID 37229825
  3. CMTM3 protects the gastric epithelial cells from apoptosis and promotes IL-8 by stabilizing NEMO during Helicobacter pylori infection. Zhang J, et al. Gut Pathog, 2023 Feb 13. PMID 36782312, Free PMC Article
  4. In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ). Wang J, et al. Cell Oncol (Dordr), 2023 Feb. PMID 36284038
  5. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. Imamura Y, et al. J Biol Chem, 2004 Jun 18. PMID 15087455

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CMTM3 Suppresses Proliferation and Osteogenic Transdifferentiation of C2C12 Myoblasts through p53 Upregulation.
    Title: CMTM3 Suppresses Proliferation and Osteogenic Transdifferentiation of C2C12 Myoblasts through p53 Upregulation.
  2. CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling.
    Title: CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling.
  3. In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARgamma).
    Title: In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 3
Names
chemokine-like factor super family 3
chemokine-like factor superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024217.3 → NP_077179.1  CKLF-like MARVEL transmembrane domain-containing protein 3

    See identical proteins and their annotated locations for NP_077179.1

    Status: VALIDATED

    Source sequence(s)
    AC121952
    Consensus CDS
    CCDS22577.1
    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Related
    ENSMUSP00000034343.5, ENSMUST00000034343.5
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105065993..105074304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531329.3 → XP_006531392.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006531392.1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  2. XM_030243740.2 → XP_030099600.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  3. XM_030243743.2 → XP_030099603.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  4. XM_030243741.1 → XP_030099601.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  5. XM_030243742.1 → XP_030099602.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  6. XM_036154257.1 → XP_036010150.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  7. XM_006531327.4 → XP_006531390.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006531390.1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Related
    ENSMUSP00000148682.2, ENSMUST00000212081.2
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  8. XM_006531326.2 → XP_006531389.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006531389.1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain

  9. XM_030243745.1 → XP_030099605.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam01284
    Location:4 → 101
    MARVEL; Membrane-associating domain

  10. XM_006531328.2 → XP_006531391.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006531391.1

    UniProtKB/Swiss-Prot
    A6H6B5, Q8BJU1, Q99LJ5, Q9D165
    UniProtKB/TrEMBL
    Q3TA49
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 149
    MARVEL; Membrane-associating domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LJ5.1 GenPept UniProtKB/Swiss-Prot:Q99LJ5

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