Vbp1 VHL binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vbp1provided by RGD
Official Full Name: VHL binding protein 1provided by RGD
Primary source: RGD:1590535
See related: AllianceGenome:RGD:1590535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable amyloid-beta binding activity; tubulin binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of amyloid fibril formation; protein folding; and tubulin complex assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
Expression: Biased expression in Thymus (RPKM 88.6), Spleen (RPKM 87.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Annotation release	Status	Assembly	Chr	Location
106	latest, but not current	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (148425046..148443505, complement)
106	latest, but not current	Rn_Celera (GCF_000002265.2)	1	AC_000069.1 (137517154..137532514, complement)

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143849 (e-PCR)
- UniSTS:233095

BE100112 (e-PCR)
- UniSTS:249775

RH144452 (e-PCR)
- UniSTS:233697

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule-based process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: VHL binding protein 1

Names: prefoldin subunit 3; von Hippel-Lindau binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.