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Mlip muscular LMNA-interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 681849, updated on 2-Nov-2024

Summary

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Symbol
Mlipprovided by RGD
Full Name
muscular LMNA-interacting proteinprovided by RGD
Primary source
RGD:1590513
See related
EnsemblRapid:ENSRNOG00000005934 AllianceGenome:RGD:1590513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CIP
Summary
Predicted to enable lamin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body; nuclear envelope; and sarcolemma. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 263.0), Muscle (RPKM 150.0) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mlip in Genome Data Viewer
Location:
8q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (86815491..87085117, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (77935087..78204725, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84409957..84634637, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480074 Neighboring gene U2 spliceosomal RNA Neighboring gene tubulointerstitial nephritis antigen Neighboring gene leucine rich repeat containing 1 Neighboring gene uncharacterized LOC120094211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. Cattin ME, et al. J Biol Chem, 2015 Oct 30. PMID 26359501, Free PMC Article
  2. Identification of a novel muscle A-type lamin-interacting protein (MLIP). Ahmady E, et al. J Biol Chem, 2011 Jun 3. PMID 21498514, Free PMC Article
  3. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. Huang ZP, et al. J Clin Invest, 2015 Nov 2. PMID 26436652, Free PMC Article
  4. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Huang ZP, et al. Circ Res, 2012 Mar 16. PMID 22343712, Free PMC Article
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear lumen ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
muscular LMNA-interacting protein
Names
cardiac Isl1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399373.1 → NP_001386302.1  muscular LMNA-interacting protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A096MJS3
    Related
    ENSRNOP00000068241.1, ENSRNOT00000076213.4
    Conserved Domains (2) summary
    PHA03307
    Location:361 → 614
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:566 → 774
    MLIP; Muscular LMNA-interacting protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    86815491..87085117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082515.2 → XP_038938443.1  muscular LMNA-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (3) summary
    PHA03307
    Location:505 → 758
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK10118
    Location:417 → 584
    PRK10118; flagellar hook length control protein FliK
    pfam15274
    Location:710 → 946
    MLIP; Muscular LMNA-interacting protein

  2. XM_039082514.2 → XP_038938442.1  muscular LMNA-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (3) summary
    PHA03307
    Location:505 → 758
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK10118
    Location:417 → 584
    PRK10118; flagellar hook length control protein FliK
    pfam15274
    Location:710 → 946
    MLIP; Muscular LMNA-interacting protein

  3. XM_063266137.1 → XP_063122207.1  muscular LMNA-interacting protein isoform X18

  4. XM_063266135.1 → XP_063122205.1  muscular LMNA-interacting protein isoform X15

  5. XM_063266136.1 → XP_063122206.1  muscular LMNA-interacting protein isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZRC1
    Related
    ENSRNOP00000080719.1, ENSRNOT00000117285.2

  6. XM_063266134.1 → XP_063122204.1  muscular LMNA-interacting protein isoform X13

  7. XM_063266132.1 → XP_063122202.1  muscular LMNA-interacting protein isoform X6

  8. XM_039082517.2 → XP_038938445.1  muscular LMNA-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:386 → 639
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:591 → 827
    MLIP; Muscular LMNA-interacting protein

  9. XM_039082516.2 → XP_038938444.1  muscular LMNA-interacting protein isoform X2

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Related
    ENSRNOP00000097271.2, ENSRNOT00000105297.2
    Conserved Domains (2) summary
    PHA03307
    Location:438 → 691
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:643 → 879
    MLIP; Muscular LMNA-interacting protein

  10. XM_039082520.2 → XP_038938448.1  muscular LMNA-interacting protein isoform X6

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Related
    ENSRNOP00000095106.2, ENSRNOT00000113615.2
    Conserved Domains (2) summary
    PHA03307
    Location:365 → 618
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:570 → 806
    MLIP; Muscular LMNA-interacting protein

  11. XM_039082521.2 → XP_038938449.1  muscular LMNA-interacting protein isoform X5

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:413 → 666
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:618 → 806
    MLIP; Muscular LMNA-interacting protein

  12. XM_039082519.2 → XP_038938447.1  muscular LMNA-interacting protein isoform X6

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:365 → 618
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:570 → 806
    MLIP; Muscular LMNA-interacting protein

  13. XM_039082522.2 → XP_038938450.1  muscular LMNA-interacting protein isoform X8

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:361 → 614
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:566 → 802
    MLIP; Muscular LMNA-interacting protein

  14. XM_039082524.2 → XP_038938452.1  muscular LMNA-interacting protein isoform X9

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:413 → 666
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:618 → 782
    MLIP; Muscular LMNA-interacting protein

  15. XM_039082525.2 → XP_038938453.1  muscular LMNA-interacting protein isoform X10

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (3) summary
    PHA03307
    Location:413 → 666
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK10118
    Location:325 → 492
    PRK10118; flagellar hook length control protein FliK
    pfam15274
    Location:687 → 760
    MLIP; Muscular LMNA-interacting protein

  16. XM_039082518.2 → XP_038938446.1  muscular LMNA-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Conserved Domains (2) summary
    PHA03307
    Location:413 → 666
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:618 → 826
    MLIP; Muscular LMNA-interacting protein

  17. XM_063266133.1 → XP_063122203.1  muscular LMNA-interacting protein isoform X11

    UniProtKB/TrEMBL
    A0A096MJS3

  18. XM_039082528.2 → XP_038938456.1  muscular LMNA-interacting protein isoform X14

    Conserved Domains (1) summary
    pfam15274
    Location:113 → 295
    MLIP; Muscular LMNA-interacting protein

  19. XM_039082527.1 → XP_038938455.1  muscular LMNA-interacting protein isoform X12

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Related
    ENSRNOP00000076453.2, ENSRNOT00000120266.2
    Conserved Domains (2) summary
    PHA03307
    Location:361 → 614
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:566 → 774
    MLIP; Muscular LMNA-interacting protein

  20. XM_039082529.1 → XP_038938457.1  muscular LMNA-interacting protein isoform X16

    Conserved Domains (1) summary
    pfam15274
    Location:113 → 271
    MLIP; Muscular LMNA-interacting protein

  21. XM_039082523.1 → XP_038938451.1  muscular LMNA-interacting protein isoform X7

    UniProtKB/Swiss-Prot
    A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    Related
    ENSRNOP00000099958.1, ENSRNOT00000143920.1
    Conserved Domains (2) summary
    PHA03307
    Location:413 → 666
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15274
    Location:618 → 802
    MLIP; Muscular LMNA-interacting protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A096MK47.2 GenPept UniProtKB/Swiss-Prot:A0A096MK47

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