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Nom1 nucleolar protein with MIF4G domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 682058, updated on 2-Nov-2024

Summary

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Official Symbol
Nom1provided by RGD
Official Full Name
nucleolar protein with MIF4G domain 1provided by RGD
Primary source
RGD:1588109
See related
EnsemblRapid:ENSRNOG00000048969 AllianceGenome:RGD:1588109
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to act upstream of or within hair follicle maturation. Predicted to be located in nucleolus. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 132.0), Adrenal (RPKM 130.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nom1 in Genome Data Viewer
Location:
4q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (6562931..6586093, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5891220..5910741, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (2340034..2356427)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486703 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene motor neuron and pancreas homeobox 1 Neighboring gene ribosomal L24 domain containing 1, pseudogene 1 Neighboring gene limb development membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Simmons HM, et al. Gene, 2005 Feb 28. PMID 15715967
  2. NOM1 targets protein phosphatase I to the nucleolus. Gunawardena SR, et al. J Biol Chem, 2008 Jan 4. PMID 17965019
  3. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hair follicle maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleolar MIF4G domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    6562931..6586093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108548.2 → XP_038964476.1  nucleolar MIF4G domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUC8, A6KJM4
    Related
    ENSRNOP00000097421.1, ENSRNOT00000100683.2
    Conserved Domains (3) summary
    smart00543
    Location:344 → 540
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    PRK00708
    Location:91 → 166
    PRK00708; twin-arginine translocase subunit TatB
    cl02653
    Location:635 → 741
    MA3; MA3 domain

  2. XM_039108550.2 → XP_038964478.1  nucleolar MIF4G domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cl02652
    Location:3 → 183
    MIF4G; MIF4G domain
    cl02653
    Location:278 → 384
    MA3; MA3 domain

  3. XM_039108549.2 → XP_038964477.1  nucleolar MIF4G domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KJM4
    Conserved Domains (2) summary
    smart00543
    Location:344 → 540
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    PRK00708
    Location:91 → 166
    PRK00708; twin-arginine translocase subunit TatB

  4. XM_063286892.1 → XP_063142962.1  nucleolar MIF4G domain-containing protein 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials