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Mcrip2 MAPK regulated corepressor interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68241, updated on 5-Mar-2024

Summary

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Official Symbol
Mcrip2provided by MGI
Official Full Name
MAPK regulated corepressor interacting protein 2provided by MGI
Primary source
MGI:MGI:1915491
See related
Ensembl:ENSMUSG00000025732 AllianceGenome:MGI:1915491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam195a; 9530058B02Rik
Summary
Predicted to be located in cytoplasmic stress granule and nucleus. Is expressed in adrenal gland and axial musculature. Orthologous to human MCRIP2 (MAPK regulated corepressor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 430.7), ovary adult (RPKM 71.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Mcrip2 in Genome Data Viewer
Location:
17 A3.3; 17 12.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26082672..26087738, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25863698..25868740, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member T2 Neighboring gene WD repeat domain 90 Neighboring gene STARR-positive B cell enhancer ABC_E10938 Neighboring gene nuclear encoded tRNA glycine 7 (anticodon CCC) Neighboring gene methyltransferase like 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Cannavino J, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34088848, Free PMC Article
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
    Title: Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAPK regulated corepressor interacting protein 2
Names
family with sequence similarity 195, member A
protein FAM195A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378771.1 → NP_001365700.1  MAPK regulated corepressor interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Conserved Domains (1) summary
    pfam14799
    Location:61 → 173
    FAM195; FAM195 family

  2. NM_001378772.1 → NP_001365701.1  MAPK regulated corepressor interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Conserved Domains (1) summary
    pfam14799
    Location:62 → 158
    FAM195; FAM195 family

  3. NM_026633.3 → NP_080909.1  MAPK regulated corepressor interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_080909.1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS28535.1
    UniProtKB/Swiss-Prot
    Q9CQB2
    UniProtKB/TrEMBL
    A0A494B9S0
    Related
    ENSMUSP00000026828.6, ENSMUST00000026828.7
    Conserved Domains (1) summary
    pfam14799
    Location:61 → 154
    FAM195; FAM195 family

RNA

  1. NR_166092.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277

  2. NR_166093.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277

  3. NR_166094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277

  4. NR_166095.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Related
    ENSMUST00000237080.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26082672..26087738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160758.1 → XP_036016651.1  MAPK regulated corepressor interacting protein 2 isoform X1

    Conserved Domains (1) summary
    pfam14799
    Location:62 → 174
    FAM195; FAM195 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQB2.1 GenPept UniProtKB/Swiss-Prot:Q9CQB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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